Analysis Tools
nervous system
| N |
• mice exhibit normal intracranial pressure
|
microgliosis
(
J:158278
)
|
• as early as 3 months and at 24 months in the lateral septal nucleus (dorsal and ventral), striatum, and cortex
|
|
• without an increase in brain weight
|
|
• mice exhibit enlargement of the third and lateral ventricles that is detected at an early age and persists, with gradual progression, throughout life
• however, the fourth ventricle, cerebral aqueduct, and choroid plexus remain normal
|
|
• at 18 and 24 months, the number of glial cells is increased and the number of neuronal cells is decreased with the dorsal lateral septal nucleus compared to in wild-type mice
|
astrocytosis
(
J:158278
)
|
• at 24 months
|
|
• at 24 months in the dorsal lateral nucleus, medial septal nucleus, striatum and cortex
|
behavior/neurological
|
• in contextual and cued fear conditioning experiments mice exhibit shorter time to resume normal activity compared with wild-type mice indicating short-term and long-term memory deficits
|
|
• mice exhibit poor performance on a rotarod (at 18 months) and more-frequent repetitive stumbling and shortened step length in a catwalk test (at 20 to 24 months) compared with wild-type mice
|
|
• at 20 to 24 months, mice exhibit unsteady, wobbly swaying gait unlike wild-type mice
|
|
• in a catwalk test at 20 to 24 months
|
renal/urinary system
|
• under mild stress
|
|
• under mild stress, mice exhibit increased urination frequency and volume compared with wild-type mice
|
immune system
microgliosis
(
J:158278
)
|
• as early as 3 months and at 24 months in the lateral septal nucleus (dorsal and ventral), striatum, and cortex
|
hematopoietic system
microgliosis
(
J:158278
)
|
• as early as 3 months and at 24 months in the lateral septal nucleus (dorsal and ventral), striatum, and cortex
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| normal pressure hydrocephalus | DOID:1572 |
OMIM:236690 |
J:158278 | |
