All Phenotypes Lgi4<tm1Sjm> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lgi4^tm1Sjm/Lgi4^tm1Sjm	involves: C57BL/6 * SJL	MGI:4849630
cx2	Adam22^tm1Sag/Adam22^tm1Sag Lgi4^tm1Sjm/Lgi4^tm1Sjm	involves: C57BL/6 * CBA * SJL	MGI:4849631

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:166449 )

• most mice die immediately after birth

nervous system

abnormal glial cell morphology ( J:166449 )

• in vitro glial differentiation of neural crest stem cells from multiple regions in the peripheral nervous system (gut and sympathetic ganglia) is impaired compared to when wild-type cells are used

• glial cells fail to adopt mature phenotypes unlike in wild-type mice

• enteric sections exhibit fewer glial cells than in wild-type mice

• fewer satellite glia surround sensory neurons in the dorsal root ganglia compared to in wild-type mice

• satellite glia cells surrounding sensory neurons in the dorsal root ganglia exhibit abnormal morphology compared to in wild-type mice

abnormal PNS glial cell morphology ( J:166449 )

• mice exhibit reduced glial cells throughout the peripheral nervous system (including enteric glia, dorsal root ganglia, and sympathetic ganglia) compared with wild-type mice

abnormal Schwann cell morphology ( J:166449 )

• Schwann cells fail to fully differentiate to a myelinating phenotype unlike in wild-type mice

abnormal sciatic nerve morphology ( J:166449 )

• thin and hypomyelinated

abnormal glial cell physiology ( J:166449 )

• glia-restricted progenitors from the gut and sympathetic ganglia exhibit reduced proliferation compared with wild-type cells

• however, glia-restricted progenitors exhibit normal apoptosis

demyelination ( J:166449 )

• of peripheral nerves

growth/size/body

decreased body size ( J:166449 )

• at P1

decreased body weight ( J:166449 )

• at P1 and P12

• at P14, mice weight one-third of wild-type mice

postnatal growth retardation ( J:166449 )

• severe after birth

limbs/digits/tail

abnormal forelimb morphology ( J:166449 )

• arthrogryposis-like paw

Allelic Composition	Adam22^tm1Sag/Adam22^tm1Sag Lgi4^tm1Sjm/Lgi4^tm1Sjm
Genetic Background	involves: C57BL/6 * CBA * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adam22^tm1Sag mutation (2 available); any Adam22 mutation (72 available)
Lgi4^tm1Sjm mutation (0 available); any Lgi4 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype