Phenotypes associated with this allele
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr2f1tm2.1Mjts mutation
(1 available);
any
Nr2f1 mutation
(24 available)
Tg(rx3-icre)1Mjam mutation
(0 available)
|
|
|
vision/eye
|
N |
• no gross defects in eye development are detected
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr2f1tm2.1Mjts mutation
(1 available);
any
Nr2f1 mutation
(24 available)
Nr2f2tm2.1Tsa mutation
(0 available);
any
Nr2f2 mutation
(27 available)
Tg(rx3-icre)1Mjam mutation
(0 available)
|
|
|
vision/eye
|
|
• at E11.5 and E14.5 expression analysis indicates that proximo-ventral cells in the presumptive retinal pigment epithelium possess neural retinal identity
• however, nasal-dorsal cells retain their retinal pigment epithelium identity
|
|
|
• at E11.5 expression analysis indicates that progenitor cells in the distal ventral optic stalk gain a neural retinal identity
• at E14.5 a neural retina like structure connects directly with the diencephalon
• at E14.5 expression analysis indicates that proximo-ventral cells in the presumptive retinal pigment epithelium possess neural retinal identity
|
|
|
• at E10.5 the optic stalk resembles the early (E9.5) optic vesicle
• at E12.5 and E14.5 the optic stalk is open ventrally
• the ventral optic stalk is not detected by morphology at E14.5
• however, expression analysis indicates optic stalk identity is maintained but that the boundary between the stalk and neural retina is shifted proximally
• expression analysis indicates that differentiation of dorsal optic stalk cells is impaired
|
|
|
• severe at E14.5
• at E12.5 and E14.5 the optic stalk is open ventrally
|
|
|
• seen at E14.5 and persists through birth
|
nervous system
pigmentation
|
|
• at E11.5 and E14.5 expression analysis indicates that proximo-ventral cells in the presumptive retinal pigment epithelium possess neural retinal identity
• however, nasal-dorsal cells retain their retinal pigment epithelium identity
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr2f1tm2.1Mjts mutation
(1 available);
any
Nr2f1 mutation
(24 available)
Nr2f2tm2.1Tsa mutation
(0 available);
any
Nr2f2 mutation
(27 available)
Tg(rx3-icre)1Mjam mutation
(0 available)
|
|
|
vision/eye
|
|
• bilaterally open optic fissure at E14.5
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr2f1tm2.1Mjts mutation
(1 available);
any
Nr2f1 mutation
(24 available)
Nr2f2tm2.1Tsa mutation
(0 available);
any
Nr2f2 mutation
(27 available)
Tg(rx3-icre)1Mjam mutation
(0 available)
|
|
|
vision/eye
|
|
• bilaterally open optic fissure at E14.5
|
Analysis Tools