Phenotypes associated with this allele

• Allele Symbol: Creb3l2^tm1Kaim
• Allele Name: targeted mutation 1, Kazunori Imaizumi
• Allele ID: MGI:4438923
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Creb3l2^tm1Kaim/Creb3l2^tm1Kaim	involves: 129S2/SvPas * C57BL/6	MGI:4438931

Genotype
MGI:4438931

hm1

• Allelic Composition: Creb3l2^tm1Kaim/Creb3l2^tm1Kaim
• Genetic Background: involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:158241 )

• mice die by suffocation shortly after birth

skeleton

abnormal craniofacial bone morphology ( J:158241 )

• hypoplastic

abnormal long bone epiphyseal plate proliferative zone ( J:158241 )

• chondrocytes in the proliferating zone are decreased in number and lack typical columnar structure unlike in wild-type mice

• however, proliferation is detected

decreased width of hypertrophic chondrocyte zone ( J:158241 )

decreased length of long bones ( J:158241 )

decreased chondrocyte number ( J:158241 )

• in the epiphyseal plate proliferating zone

chondrodystrophy ( J:158241 )

• severe

craniofacial

abnormal craniofacial bone morphology ( J:158241 )

• hypoplastic

protruding tongue ( J:158241 )

limbs/digits/tail

short limbs ( J:158241 )

growth/size/body

protruding tongue ( J:158241 )

abnormal thoracic cavity morphology ( J:158241 )

• immature

distended abdomen ( J:158241 )

digestive/alimentary system

protruding tongue ( J:158241 )