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Allele Symbol Allele Name Allele ID |
Tg(Thy1-APPDutch)#Jckr transgene insertion, Mathias Jucker MGI:4438890 |
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| Summary |
7 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mutants exhibit a similar level of cerebral amyloid angiopathy as in single Tg(Thy1-AppDutch)#Jckr transgenic mice
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• mutants exhibit a similar level of cerebral amyloid angiopathy as in single Tg(Thy1-AppDutch)#Jckr transgenic mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• number and severity of amyloid beta-immunoreactive vessels is increased compared to single Tg(Thy1-AppDutch)#Jckr mice indicating the development of more severe cerebral amyloid angiopathy
• amyloid beta deposits are increased in neurons of the neocortex and hippocampus
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• number and severity of amyloid beta-immunoreactive vessels is increased compared to single Tg(Thy1-AppDutch)#Jckr mice indicating the development of more severe cerebral amyloid angiopathy
• amyloid beta deposits are increased in neurons of the neocortex and hippocampus
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| cerebral amyloid angiopathy | DOID:9246 | J:178230 | ||
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• mutants exhibit a similar level of cerebral amyloid angiopathy as in single Tg(Thy1-AppDutch)#Jckr transgenic mice
|
|
• mutants exhibit a similar level of cerebral amyloid angiopathy as in single Tg(Thy1-AppDutch)#Jckr transgenic mice
|
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|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• extensive vascular amyloid in the thalamus
• parenchymal amyloid in the cortex and some amyloid in the subiculum
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| cerebral amyloid angiopathy | DOID:9246 | J:162531 | ||
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• starting at 12 weeks of age parenchymal amyloid in the neocortex and hippocampus
• at 10 months, massive diffuse and compact parenchymal amyloid are found in virtually all brain regions
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• starting at 12 weeks of age parenchymal amyloid in the neocortex and hippocampus
• at 10 months, massive diffuse and compact parenchymal amyloid are found in virtually all brain regions
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| cerebral amyloid angiopathy | DOID:9246 | J:92796 | ||
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• massive parenchymal amyloidosis is observed throughout the entire brain with the exception of the cerellebum
• modest vascular amyloid also present
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• vascular amyloid deposition at approximately 22-25 months with female mice
having an earlier onset than males
(J:92796)
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• cerebrovascular amyloid restricted to leptomeningeal and cortical vessels
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• amyloid-laden vessels show a severe loss of smooth muscle cells
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• fresh hemorrhages, as well as indications of previous hemorrhages are found
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• amyloid-laden vessels show a severe loss of smooth muscle cells
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• an irregular thickening of the basement membrane with amorphous material in some vessels
• amyloid fibrils within the basement membrane, predominantly on the adventitial side
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• vascular amyloid deposition at approximately 22-25 months with female mice
having an earlier onset than males
(J:92796)
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• cerebrovascular amyloid restricted to leptomeningeal and cortical vessels
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| cerebral amyloid angiopathy | DOID:9246 | J:92796 , J:162531 | ||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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