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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ednrbtm1.1Nat
targeted mutation 1.1, Jeremy Nathans
MGI:4438377
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Ednrbtm1.1Nat/Ednrbtm1.2Nat
Igs1tm11(CAG-Bgeo,-Edn2)Nat/Igs1+
Tg(Pax6-cre,GFP)2Pgr/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5544090


Genotype
MGI:5544090
cn1
Allelic
Composition		 Ednrbtm1.1Nat/Ednrbtm1.2Nat
Igs1tm11(CAG-Bgeo,-Edn2)Nat/Igs1+
Tg(Pax6-cre,GFP)2Pgr/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ednrbtm1.1Nat mutation (1 available); any Ednrb mutation (107 available)
Ednrbtm1.2Nat mutation (0 available); any Ednrb mutation (107 available)
Igs1tm11(CAG-Bgeo,-Edn2)Nat mutation (1 available); any Igs1 mutation (10 available)
Tg(Pax6-cre,GFP)2Pgr mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
abnormal retina vasculature morphology ( J:201133 )
• removal of Ednrb appears to sensitize the vasculature as growth arrests proximal to the front of cre-mediated recombination

cardiovascular system
abnormal retina vasculature morphology ( J:201133 )
• removal of Ednrb appears to sensitize the vasculature as growth arrests proximal to the front of cre-mediated recombination




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory