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Allele Symbol Allele Name Allele ID |
Tg(HTT*)1Xwy transgene insertion 1, X William Yang MGI:4438230 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice exhibit decreased forebrain weight compared with wild-type mice
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• mice exhibit a 17% reduction in striatal volume compared with wild-type mice
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• mice exhibit a 17% reduction in cortical volume compared with wild-type mice
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• at 2 months, mice exhibit protein aggregates that worsen with age unlike in wild-type mice
• at 12 months, mice exhibit protein aggregates in the cortex and striatum unlike in wild-type mice
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• at 12 months, mice exhibit selective neuropathy unlike wild-type mice
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• at 12 months, mice exhibit depressive-like behavior unlike wild-type mice
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• mice spend less time in the light portion of a light/dark box than wild-type mice
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• starting at 2 months and worsening with age
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Huntington's disease | DOID:12858 |
OMIM:143100 |
J:157723 | |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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