Analysis Tools
mortality/aging
|
• homozygous mice die postnatally due to immune defects
• no specific age mentioned
|
|
Allele Symbol Allele Name Allele ID |
Stat3tm4Vpo targeted mutation 4, Valeria Poli MGI:4438059 |
||||||||||||
| Summary |
2 genotypes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• homozygous mice die postnatally due to immune defects
• no specific age mentioned
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• mice develop palpable tumors significantly earlier than their littermate controls only carrying the transgene
• the presence of larger, more diffused and advanced neoplastic lesions in whole mount mammary gland preparations performed at 7, 12, and 17 weeks of age than their littermate controls only carrying the transgene
• normal proliferation rates in tumor lesions as assessed by PCNA staining
|
|
• invasive carcinomas at 12 weeks
• tumor cells group in solid masses with small aggregates invading the surrounding fibroadipose tissue
• only atypical hyperplastic foci and few in situ carcinomas in the littermate controls only carrying the transgene
|
|
• strongly enhanced Matrigel invasion potential in cell lines derived from tumors in mutant mice
• strongly enhanced metastatic potential, producing more and faster growing lung metastases both at 5 and 3 weeks when injected into nude mice
|
|
• produce tumors faster in nude mice, reaching a diameter of 10 mm 5 weeks after injection of the cell lines derived from tumors in mutant mice
• tumors produced by injection of the cell lines derived from tumors in transgene control mice grow much slower and never reach the 10-mm size
|
|
• mice develop palpable tumors significantly earlier than their littermate controls only carrying the transgene
• the presence of larger, more diffused and advanced neoplastic lesions in whole mount mammary gland preparations performed at 7, 12, and 17 weeks of age than their littermate controls only carrying the transgene
• normal proliferation rates in tumor lesions as assessed by PCNA staining
|
|
• invasive carcinomas at 12 weeks
• tumor cells group in solid masses with small aggregates invading the surrounding fibroadipose tissue
• only atypical hyperplastic foci and few in situ carcinomas in the littermate controls only carrying the transgene
|
|
• absence of cortical actin and presence of actin stress fibers in cell lines derived from tumors in mutant mice
|
|
• discontinuous E-cadherin, beta-catenin, and Zo-1 distribution in cell lines derived from tumors in mutant mice
|
|
• reduced TUNEL-positive apoptotic nuclei in tumor lesions
|
|
• increased migration (>2 fold) in cell lines derived from tumors in mutant mice
|
|
• mice develop palpable tumors significantly earlier than their littermate controls only carrying the transgene
• the presence of larger, more diffused and advanced neoplastic lesions in whole mount mammary gland preparations performed at 7, 12, and 17 weeks of age than their littermate controls only carrying the transgene
• normal proliferation rates in tumor lesions as assessed by PCNA staining
|
|
• invasive carcinomas at 12 weeks
• tumor cells group in solid masses with small aggregates invading the surrounding fibroadipose tissue
• only atypical hyperplastic foci and few in situ carcinomas in the littermate controls only carrying the transgene
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 05/07/2024 MGI 6.23 |
|
|
|
||