All Phenotypes Nphp1<tm1Jgg> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Nphp1^tm1Jgg
targeted mutation 1, Joseph G Gleeson
MGI:4437792

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nphp1^tm1Jgg/Nphp1^tm1Jgg	involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * NMRI	MGI:4437800
cn2	Ahi1^tm1Jgg/Ahi1^tm2.1Jgg Nphp1^tm1Jgg/Nphp1⁺ Tg(Pax6-cre,GFP)2Pgr/0	involves: 129 * C57BL/6 * FVB/N * NMRI	MGI:4437798
cx3	Ahi1^tm1Jgg/Ahi1⁺ Nphp1^tm1Jgg/Nphp1^tm1Jgg	involves: 129 * C57BL/6 * FVB/N * NMRI	MGI:4437801

Allelic Composition	Nphp1^tm1Jgg/Nphp1^tm1Jgg
Genetic Background	involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * NMRI

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nphp1^tm1Jgg mutation (1 available); any Nphp1 mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

thin retina outer nuclear layer ( J:158019 )

• outer retinal thickness is reduced compared to in wild-type mice

retina degeneration ( J:158019 )

• at 2 months, mice exhibit slight retinal degeneration that progresses gradually

Allelic Composition	Ahi1^tm1Jgg/Ahi1^tm2.1Jgg Nphp1^tm1Jgg/Nphp1⁺ Tg(Pax6-cre,GFP)2Pgr/0
Genetic Background	involves: 129 * C57BL/6 * FVB/N * NMRI

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ahi1^tm1Jgg mutation (1 available); any Ahi1 mutation (80 available)
Ahi1^tm2.1Jgg mutation (1 available); any Ahi1 mutation (80 available)
Nphp1^tm1Jgg mutation (1 available); any Nphp1 mutation (26 available)
Tg(Pax6-cre,GFP)2Pgr mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

thin retina outer nuclear layer ( J:158019 )

Allelic Composition	Ahi1^tm1Jgg/Ahi1⁺ Nphp1^tm1Jgg/Nphp1^tm1Jgg
Genetic Background	involves: 129 * C57BL/6 * FVB/N * NMRI

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ahi1^tm1Jgg mutation (1 available); any Ahi1 mutation (80 available)
Nphp1^tm1Jgg mutation (1 available); any Nphp1 mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

thin retina outer nuclear layer ( J:158019 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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