Analysis Tools
immune system
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• mice exhibit normal macrophage migration and chemotactic response
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• following ovalbumin immunization and challenge, fewer eosinophils infiltrate the respiratory tract compared to in similarly treated wild-type mice
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• following ovalbumin immunization and challenge, mice exhibit reduced CD11c+ dendritic cells migrate into the bronchial lymph nodes, eosinophils infiltrate the respiratory tract, and IL4 in the bronchoalveolar lavage fluid compared with similarly treated wild-type mice
• however, T helper 1 response following viral infection is normal
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• in vitro, dendritic cell chemotaxis in response to MIP-1alpha (Ccl3) is impaired compared with similarly treated wild-type cells
• in vivo, mature dendritic cells from the skin exhibit impaired migration to the lymph nodes compared with wild-type cells
• following ovalbumin immunization and challenge, fewer CD11c+ dendritic cells migrate into the bronchial lymph nodes compared to in similarly treated wild-type mice
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• following ovalbumin immunization and challenge, less IL4 is found within the bronchoalveolar lavage fluid compared to in similarly treated wild-type mice
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hematopoietic system
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• following ovalbumin immunization and challenge, fewer eosinophils infiltrate the respiratory tract compared to in similarly treated wild-type mice
|
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• following ovalbumin immunization and challenge, mice exhibit reduced CD11c+ dendritic cells migrate into the bronchial lymph nodes, eosinophils infiltrate the respiratory tract, and IL4 in the bronchoalveolar lavage fluid compared with similarly treated wild-type mice
• however, T helper 1 response following viral infection is normal
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