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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Myh6*/tetO-Capn1)L2Gwd
transgene insertion L2, Gerald W Dorn II
MGI:4437466
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
 		Tg(Myh6*/tetO-Capn1)L2Gwd/0 involves: FVB/N MGI:4437577


Genotype
MGI:4437577
tg1
Allelic
Composition		 Tg(Myh6*/tetO-Capn1)L2Gwd/0
Genetic
Background		 involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Myh6*/tetO-Capn1)L2Gwd mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:133797 )
• mice treated with doxycycline during the first week of life die within the first 2 weeks of life

cardiovascular system
increased heart weight ( J:133797 )
• when treated with doxycycline during the first week of life
abnormal heart left ventricle morphology ( J:133797 )
• following neonatal induction with doxycycline, mice exhibit increased left ventricular end-diastolic and end-systolic dimension compared with wild-type mice
decreased heart ventricle muscle contractility ( J:133797 )
• following neonatal induction with doxycycline

muscle
decreased heart ventricle muscle contractility ( J:133797 )
• following neonatal induction with doxycycline

growth/size/body
increased heart weight ( J:133797 )
• when treated with doxycycline during the first week of life




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory