Analysis Tools
cardiovascular system
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• myocytes are variable in size with frequent intracellular inclusions and increased cardiomyocyte cross-sectional area compared to in wild-type mice
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• following neonatal induction with doxycycline, mice exhibit increased left ventricular end-diastolic and end-systolic dimension compared with wild-type mice
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• slowly progressive
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• ventricular ejection is decreased compared to in wild-type mice
• in response to dobutamine, the peak rate of change of left ventricular pressure increase is less than in similarly treated wild-type mice
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• 50% of mice exhibit atrial arrhythmia unlike wild-type mice
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homeostasis/metabolism
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• in response to dobutamine, the peak rate of change of left ventricular pressure increase is less than in similarly treated wild-type mice
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muscle
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• myocytes are variable in size with frequent intracellular inclusions and increased cardiomyocyte cross-sectional area compared to in wild-type mice
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• slowly progressive
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• ventricular ejection is decreased compared to in wild-type mice
• in response to dobutamine, the peak rate of change of left ventricular pressure increase is less than in similarly treated wild-type mice
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