Analysis Tools
immune system
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• CD4+ T cells stimulated with anti-CD3 and anti-CD-28 antibodies exhibit reduced proliferation compared with similarly treated wild-type cells
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• adoptive transfer experiments demonstrate that the defect in TH2 cytokine expression is cell intrinsic
• mice exhibit decreased TH2 cell differentiation, as measured by IL4, IL5, and IL13 production, in vitro and in vivo in an asthma model and in response to challenge with soluble egg antigen compared with similarly treated wild-type mice
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• in the bronchoalveolar lavage fluid of mice treated with ovalbumin by intraperitoneal injection and intranasal challenge
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• in the bronchoalveolar lavage fluid of mice treated with ovalbumin by intraperitoneal injection and intranasal challenge
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• in the bronchoalveolar lavage fluid of mice treated with ovalbumin by intraperitoneal injection and intranasal challenge
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• in the bronchoalveolar lavage fluid of mice treated with ovalbumin by intraperitoneal injection and intranasal challenge
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• under T helper neutral or Th1 conditions, fewer CD4+ T cells produce IFN-gamma than similarly treated wild-type mice
• splenocytes from mice exposed to soluble egg antigen produce less IFN-gamma than cells from similarly treated wild-type mice
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• under TH2 differentiation in the presence of increased doses of exogenous IL-4, fewer CD4+ T cells produce IL13 than similarly treated wild-type cells
• splenocytes from mice exposed to ovalbumin in complete Freund's adjuvant produce less IL13 than cells from similarly treated wild-type mice
• splenocytes from mice exposed to soluble egg antigen produce less IL13 than cells from similarly treated wild-type mice
• lung associated lymph node cells from mice treated with ovalbumin by intraperitoneal injection and intranasal challenge produce less IL13 than cells from similarly treated wild-type mice
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• under TH-17 conditions, more CD4+ T cells produce IL17 than similarly treated wild-type cells
• however, treatment with anti-IFN-gamma and IL-4 antibodies diminishes this difference and mice exposed to ovalbumin in complete Freund's adjuvant or egg soluble antigen produce normal amounts of IL17
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• CD4+ T cells stimulated with anti-CD3 and anti-CD-28 antibodies exhibit reduced IL2 production compared with similarly treated wild-type cells
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• under TH2 differentiation in the presence of increased doses of exogenous IL-4, fewer CD4+ T cells produce IL4 than similarly treated wild-type cells
• splenocytes from mice exposed to ovalbumin in complete Freund's adjuvant produce less IL4 than cells from similarly treated wild-type mice
• splenocytes from mice exposed to soluble egg antigen produce less IL4 than cells from similarly treated wild-type mice
• lung associated lymph node cells from mice treated with ovalbumin by intraperitoneal injection and intranasal challenge produce less IL4 than cells from similarly treated wild-type mice
• however, high doses of exogenous IL4 restores production in CD4+ T cells
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• under TH2 differentiation in the presence of increased doses of exogenous IL-4, fewer CD4+ T cells produce IL5 than similarly treated wild-type cells
• splenocytes from mice exposed to ovalbumin in complete Freund's adjuvant produce less IL5 than cells from similarly treated wild-type mice
• splenocytes from mice exposed to soluble egg antigen produce less IL5 than cells from similarly treated wild-type mice
• lung associated lymph node cells from mice treated with ovalbumin by intraperitoneal injection and intranasal challenge produce less IL5 than cells from similarly treated wild-type mice
• however, high doses of exogenous IL4 restores production in CD4+ T cells
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hematopoietic system
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• CD4+ T cells stimulated with anti-CD3 and anti-CD-28 antibodies exhibit reduced proliferation compared with similarly treated wild-type cells
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• adoptive transfer experiments demonstrate that the defect in TH2 cytokine expression is cell intrinsic
• mice exhibit decreased TH2 cell differentiation, as measured by IL4, IL5, and IL13 production, in vitro and in vivo in an asthma model and in response to challenge with soluble egg antigen compared with similarly treated wild-type mice
|
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• in the bronchoalveolar lavage fluid of mice treated with ovalbumin by intraperitoneal injection and intranasal challenge
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• in the bronchoalveolar lavage fluid of mice treated with ovalbumin by intraperitoneal injection and intranasal challenge
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• in the bronchoalveolar lavage fluid of mice treated with ovalbumin by intraperitoneal injection and intranasal challenge
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• in the bronchoalveolar lavage fluid of mice treated with ovalbumin by intraperitoneal injection and intranasal challenge
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cellular
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• CD4+ T cells stimulated with anti-CD3 and anti-CD-28 antibodies exhibit reduced proliferation compared with similarly treated wild-type cells
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