Phenotypes associated with this allele

• Allele Symbol: Tg(Tyr-TAg)BJjw
• Allele Name: transgene insertion B, Jolene J Windle
• Allele ID: MGI:4437002
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Tyr-TAg)BJjw/0	involves: BALB/cAnNHsd * C57BL/6NHsd	MGI:4437011

Genotype
MGI:4437011

tg1

• Allelic Composition: Tg(Tyr-TAg)BJjw/0
• Genetic Background: involves: BALB/cAnNHsd * C57BL/6NHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased retina tumor incidence ( J:52122 )

• by 8 weeks, mice develop retinal tumors with choroidal invasion (by 20 weeks), extraocular extension, and metastasis unlike wild-type mice

• treatment with dacarbazine reduces tumor size

increased choroid tumor incidence ( J:52122 )

• at 18 to 20 weeks, mice develop tumors with cytologic characteristics of human choroidal malignant melanoma unlike wild-type mice

increased iris tumor incidence ( J:52122 )

• one mouse developed an adenoma of the iris pigmented epithelium unlike wild-type mice

vision/eye

increased retina tumor incidence ( J:52122 )

• by 8 weeks, mice develop retinal tumors with choroidal invasion (by 20 weeks), extraocular extension, and metastasis unlike wild-type mice

• treatment with dacarbazine reduces tumor size

increased choroid tumor incidence ( J:52122 )

• at 18 to 20 weeks, mice develop tumors with cytologic characteristics of human choroidal malignant melanoma unlike wild-type mice

increased iris tumor incidence ( J:52122 )

• one mouse developed an adenoma of the iris pigmented epithelium unlike wild-type mice