All Phenotypes Foxp3<tm8Ayr> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Foxp3^tm8Ayr
targeted mutation 8, Alexander Y Rudensky
MGI:4436759

Summary

2 genotypes

Allelic Composition	Foxp3^tm8Ayr/Foxp3⁺
Genetic Background	B6.129-Foxp3^tm8Ayr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxp3^tm8Ayr mutation (0 available); any Foxp3 mutation (57 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:157377 )

• heterozygous female mice are healthy

Allelic Composition	Foxp3^tm8Ayr/Y
Genetic Background	B6.129-Foxp3^tm8Ayr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxp3^tm8Ayr mutation (0 available); any Foxp3 mutation (57 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:157377 )

• males die by around 4 weeks

immune system

autoimmune response ( J:157377 )

• male mice develope severe autoimmunity

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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