All Phenotypes Pdk1<tm1a(EUCOMM)Hmgu> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Pdk1^{tm1a(EUCOMM)Hmgu}
targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH
MGI:4436144

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pdk1^{tm1a(EUCOMM)Hmgu}/Pdk1^{tm1a(EUCOMM)Hmgu}	involves: C57BL/6N	MGI:6712411
cn2	Pdk1^{tm1a(EUCOMM)Hmgu}/Pdk1^{tm1a(EUCOMM)Hmgu} Pdk2^tm1Rhar/Pdk2^tm1Rhar	involves: 129S1/Sv * 129X1/SvJ * C57BL/6N	MGI:6712415
cx3	Pdk1^{tm1a(EUCOMM)Hmgu}/Pdk1^{tm1a(EUCOMM)Hmgu} Pdk2^tm1Rhar/Pdk2^tm1Rhar Pdk3^em1Eze/Pdk3^em1Eze Pdk4^tm1Rhar/Pdk4^tm1Rhar	involves: 129 * C57BL/6J * C57BL/6N	MGI:6712416
cx4	Pdk1^{tm1a(EUCOMM)Hmgu}/Pdk1^{tm1a(EUCOMM)Hmgu} Pdk2^tm1Rhar/Pdk2^tm1Rhar Pdk4^tm1Rhar/Pdk4^tm1Rhar	involves: 129S1/Sv * 129X1/SvJ * C57BL/6N	MGI:6712269
cx5	Pdk1^{tm1a(EUCOMM)Hmgu}/Pdk1^{tm1a(EUCOMM)Hmgu} Pdk4^tm1Rhar/Pdk4^tm1Rhar	involves: 129S1/Sv * 129X1/SvJ * C57BL/6N	MGI:6712417

Allelic Composition	Pdk1^{tm1a(EUCOMM)Hmgu}/Pdk1^{tm1a(EUCOMM)Hmgu}
Genetic Background	involves: C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdk1^{tm1a(EUCOMM)Hmgu} mutation (0 available); any Pdk1 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:303714 )

• mice are viable

reproductive system

reproductive system phenotype ( J:303714 )

• mice are fertile

skeleton

skeleton phenotype ( J:303714 )

• mice exhibit normal embryonic bone development

Allelic Composition	Pdk1^{tm1a(EUCOMM)Hmgu}/Pdk1^{tm1a(EUCOMM)Hmgu} Pdk2^tm1Rhar/Pdk2^tm1Rhar
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:303714 )

• mice are viable

reproductive system

reproductive system phenotype ( J:303714 )

• mice are fertile

skeleton

skeleton phenotype ( J:303714 )

• mice exhibit normal embryonic bone development

Allelic Composition	Pdk1^{tm1a(EUCOMM)Hmgu}/Pdk1^{tm1a(EUCOMM)Hmgu} Pdk2^tm1Rhar/Pdk2^tm1Rhar Pdk3^em1Eze/Pdk3^em1Eze Pdk4^tm1Rhar/Pdk4^tm1Rhar
Genetic Background	involves: 129 * C57BL/6J * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdk1^{tm1a(EUCOMM)Hmgu} mutation (0 available); any Pdk1 mutation (27 available)
Pdk2^tm1Rhar mutation (1 available); any Pdk2 mutation (22 available)
Pdk3^em1Eze mutation (0 available); any Pdk3 mutation (7 available)
Pdk4^tm1Rhar mutation (1 available); any Pdk4 mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:303714 )

• mice die between P0 and P4

homeostasis/metabolism

decreased circulating glucose level ( J:303714 )

• at P1, but not E18.5

increased circulating ketone body level ( J:303714 )

• increased serum 3-beta-hydroxybutyrate levels at P1, but not E18.5

decreased circulating lactate level ( J:303714 )

abnormal circulating protein level ( J:303714 )

• decreased pyruvate and lactate serum levels

skeleton

skeleton phenotype ( J:303714 )

N	• mice exhibit normal embryonic bone development

Allelic Composition	Pdk1^{tm1a(EUCOMM)Hmgu}/Pdk1^{tm1a(EUCOMM)Hmgu} Pdk2^tm1Rhar/Pdk2^tm1Rhar Pdk4^tm1Rhar/Pdk4^tm1Rhar
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdk1^{tm1a(EUCOMM)Hmgu} mutation (0 available); any Pdk1 mutation (27 available)
Pdk2^tm1Rhar mutation (1 available); any Pdk2 mutation (22 available)
Pdk4^tm1Rhar mutation (1 available); any Pdk4 mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:303714 )

• mice are viable

reproductive system

reproductive system phenotype ( J:303714 )

• mice are fertile

skeleton

skeleton phenotype ( J:303714 )

• mice exhibit normal embryonic bone development

Allelic Composition	Pdk1^{tm1a(EUCOMM)Hmgu}/Pdk1^{tm1a(EUCOMM)Hmgu} Pdk4^tm1Rhar/Pdk4^tm1Rhar
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdk1^{tm1a(EUCOMM)Hmgu} mutation (0 available); any Pdk1 mutation (27 available)
Pdk4^tm1Rhar mutation (1 available); any Pdk4 mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:303714 )

• mice are viable

reproductive system

reproductive system phenotype ( J:303714 )

• mice are fertile

skeleton

skeleton phenotype ( J:303714 )

• mice exhibit normal embryonic bone development

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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