Phenotypes associated with this allele

• Allele Symbol: Flvcr2^{tm1a(EUCOMM)Hmgu}
• Allele Name: targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:4435324
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Flvcr2^tm1a(EUCOMM)Hmgu/Flvcr2^tm1a(EUCOMM)Hmgu	C57BL/6N-Flvcr2^tm1a(EUCOMM)Hmgu/Wtsi	MGI:5883881
ht2	Flvcr2^tm1a(EUCOMM)Hmgu/Flvcr2^+	C57BL/6N-Flvcr2^tm1a(EUCOMM)Hmgu/Wtsi	MGI:6771980

Genotype
MGI:5883881

hm1

• Allelic Composition: Flvcr2^{tm1a(EUCOMM)Hmgu}/Flvcr2^{tm1a(EUCOMM)Hmgu}
• Genetic Background: C57BL/6N-Flvcr2^{tm1a(EUCOMM)Hmgu}/Wtsi
• Cell Lines: HEPD0572_8_F01

Data Sources

IMPC Data for Flvcr2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

absent segment of posterior cerebral artery ( J:239583 )

DMDD

abnormal vein morphology ( J:239583 )

DMDD

abnormal ductus venosus valve morphology ( J:239583 )

DMDD

absent ductus venosus valve ( J:239583 )

DMDD

hepatic portal vein stenosis ( J:239583 )

DMDD

abnormal inferior vena cava morphology ( J:239583 )

DMDD

dual inferior vena cava ( J:239583 )

DMDD

embryo

abnormal Mullerian duct topology ( J:239583 )

DMDD

abnormal Wolffian duct morphology ( J:239583 )

DMDD

immune system

blood in lymph vessels ( J:239583 )

DMDD

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - WTSI

neoplasm

increased hemangioma incidence ( J:239583 )

DMDD

embryo tumor ( J:239583 )

DMDD

nervous system

absent segment of posterior cerebral artery ( J:239583 )

DMDD

abnormal hypoglossal nerve topology ( J:239583 )

DMDD

thin hypoglossal nerve ( J:239583 )

DMDD

respiratory system

abnormal lung morphology ( J:239583 )

DMDD

Genotype
MGI:6771980

ht2

• Allelic Composition: Flvcr2^{tm1a(EUCOMM)Hmgu}/Flvcr2⁺
• Genetic Background: C57BL/6N-Flvcr2^{tm1a(EUCOMM)Hmgu}/Wtsi
• Cell Lines: HEPD0572_8_F01

Data Sources

IMPC Data for Flvcr2

homeostasis/metabolism

increased circulating cholesterol level ( J:211773 )

♂

IMPC - WTSI

increased circulating HDL cholesterol level ( J:211773 )

♂

IMPC - WTSI

increased circulating LDL cholesterol level ( J:211773 )

♂

IMPC - WTSI