All Phenotypes Fanca<tm1a(EUCOMM)Wtsi> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Fanca^{tm1a(EUCOMM)Wtsi}
targeted mutation 1a, Wellcome Trust Sanger Institute
MGI:4434431

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fanca^{tm1a(EUCOMM)Wtsi}/Fanca^{tm1a(EUCOMM)Wtsi}	involves: C57BL/6N	MGI:5608998

Allelic Composition	Fanca^{tm1a(EUCOMM)Wtsi}/Fanca^{tm1a(EUCOMM)Wtsi}
Genetic Background	involves: C57BL/6N
Cell Lines	EPD0175_5_B09

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fanca^{tm1a(EUCOMM)Wtsi} mutation (1 available); any Fanca mutation (81 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

increased sensitivity to induced cell death ( J:188123 )

• B cells, erythroid progenitor and granulocyte-macrophage progenitor cells are more sensitive to acetaldehyde

homeostasis/metabolism

increased physiological sensitivity to xenobiotic ( J:188123 )

• B cells, erythroid progenitor and granulocyte-macrophage progenitor cells are more sensitive to acetaldehyde

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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