Phenotypes associated with this allele

• Allele Symbol: Adam17^{tm1a(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4434074
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Adam17^tm1a(EUCOMM)Wtsi/Adam17^+	B6JTyr;B6N-Adam17^tm1a(EUCOMM)Wtsi/Wtsi	MGI:5781558
ht2	Adam17^tm1a(EUCOMM)Wtsi/Adam17^+	involves: C57BL/6 * C57BL/6N	MGI:5790835

Genotype
MGI:5781558

ht1

• Allelic Composition: Adam17^{tm1a(EUCOMM)Wtsi}/Adam17⁺
• Genetic Background: B6JTyr;B6N-Adam17^{tm1a(EUCOMM)Wtsi}/Wtsi
• Cell Lines: EPD0051_2_D12

Data Sources

IMPC Data for Adam17

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

abnormal vibrissa morphology ( J:175295 )

♂

IMPC - WTSI

growth/size/body

increased body weight ( J:165965 )

IMPC - WTSI

Genotype
MGI:5790835

ht2

• Allelic Composition: Adam17^{tm1a(EUCOMM)Wtsi}/Adam17⁺
• Genetic Background: involves: C57BL/6 * C57BL/6N
• Cell Lines: EPD0051_2_D12

hematopoietic system

myeloid hyperplasia ( J:213427 )

• marked, in 2/4 animals tested

increased erythrocyte cell number ( J:213427 )

• splenic erythroid hyperplasia

immune system

myeloid hyperplasia ( J:213427 )

• marked, in 2/4 animals tested

mortality/aging

lethality, incomplete penetrance ( J:213427 )

skeleton

increased bone mineral content ( J:213427 )