All Phenotypes Smc3<tm1a(EUCOMM)Wtsi> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Smc3^{tm1a(EUCOMM)Wtsi}
targeted mutation 1a, Wellcome Trust Sanger Institute
MGI:4434007

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Smc3^{tm1a(EUCOMM)Wtsi}/Smc3^{tm1a(EUCOMM)Wtsi}	B6Dnk;B6Brd;B6N-Tyr^c-Brd Smc3^{tm1a(EUCOMM)Wtsi}/WtsiH	MGI:6263522
hm2	Smc3^{tm1a(EUCOMM)Wtsi}/Smc3^{tm1a(EUCOMM)Wtsi}	involves: C57BL/6N	MGI:5544025
ht3	Smc3^{tm1a(EUCOMM)Wtsi}/Smc3⁺	B6Dnk;B6Brd;B6N-Tyr^c-Brd Smc3^{tm1a(EUCOMM)Wtsi}/WtsiH	MGI:5781751
ht4	Smc3^{tm1a(EUCOMM)Wtsi}/Smc3⁺	involves: C57BL/6N	MGI:5544026

Allelic Composition	Smc3^{tm1a(EUCOMM)Wtsi}/Smc3^{tm1a(EUCOMM)Wtsi}
Genetic Background	B6Dnk;B6Brd;B6N-Tyr^c-Brd Smc3^{tm1a(EUCOMM)Wtsi}/WtsiH
Cell Lines	EPD0070_2_G01

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smc3^{tm1a(EUCOMM)Wtsi} mutation (2 available); any Smc3 mutation (47 available)

Data Sources

IMPC Data for Smc3

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - WTSI

Allelic Composition	Smc3^{tm1a(EUCOMM)Wtsi}/Smc3^{tm1a(EUCOMM)Wtsi}
Genetic Background	involves: C57BL/6N
Cell Lines	EPD0070_2_G01

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smc3^{tm1a(EUCOMM)Wtsi} mutation (2 available); any Smc3 mutation (47 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:200082 )

• mice die prior to E14.5

Allelic Composition	Smc3^{tm1a(EUCOMM)Wtsi}/Smc3⁺
Genetic Background	B6Dnk;B6Brd;B6N-Tyr^c-Brd Smc3^{tm1a(EUCOMM)Wtsi}/WtsiH
Cell Lines	EPD0070_2_G01

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smc3^{tm1a(EUCOMM)Wtsi} mutation (2 available); any Smc3 mutation (47 available)

Data Sources

IMPC Data for Smc3

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

adipose tissue

decreased total body fat amount ( J:175295 )

IMPC - WTSI

growth/size/body

decreased lean body mass ( J:175295 )

IMPC - WTSI

decreased body weight ( J:175295 )

IMPC - WTSI

hematopoietic system

decreased mean corpuscular hemoglobin ( J:175295 )

IMPC - WTSI

integument

abnormal coat/hair pigmentation ( J:175295 )

IMPC - WTSI

pigmentation

abnormal coat/hair pigmentation ( J:175295 )

IMPC - WTSI

skeleton

decreased bone mineral content ( J:175295 )

IMPC - WTSI

Allelic Composition	Smc3^{tm1a(EUCOMM)Wtsi}/Smc3⁺
Genetic Background	involves: C57BL/6N
Cell Lines	EPD0070_2_G01

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smc3^{tm1a(EUCOMM)Wtsi} mutation (2 available); any Smc3 mutation (47 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:200082 )

• reduced viability at P14

immune system

increased T cell number ( J:200082 )

• helper and cytotoxic T cells

growth/size/body

decreased body weight ( J:200082 )

craniofacial

abnormal craniofacial morphology ( J:200082 )

hematopoietic system

increased T cell number ( J:200082 )

• helper and cytotoxic T cells

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