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Allele Symbol Allele Name Allele ID |
Ttll3tm1a(EUCOMM)Wtsi targeted mutation 1a, Wellcome Trust Sanger Institute MGI:4433856 |
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| Summary |
3 genotypes
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Data Sources
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• cultured colon epithelium cells grown for 2 days under serum starvation exhibit a 3-fold decrease in the number of ciliated colon epithelium cells compared to controls
• however, MEFs grow primary cilia similarly to control MEFs decrease in the number of cilia per crypt in the colon
• colon epithelium shows a reduced number of primary cilia
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• decrease in the number of cilia per crypt in the colon
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• mice exhibit a higher proliferation rate in the colon that is coupled to a faster turnover of epithelial cells in the crypts
• histologically, however, colon tissue shows no obvious changes
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• colon epithelium cells divide more rapidly, with 45% of colon epithelium cells containing >2n DNA compared to 20% of wild-type cells, indicating an increase in the number of cells that are in S or in G2 phase/metaphase of the cell cycle and a higher mitotic activity
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• in a model of colitis-associated carcinogenesis (intraperitoneal injection of azoxymethane and subsequent periodic administration of dextrane sodium sulfate), mutants show an increase in tumor incidence, increased total number of lesions, and increased tumor size
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• in a model of colitis-associated carcinogenesis (intraperitoneal injection of azoxymethane and subsequent periodic administration of dextrane sodium sulfate), mutants show an increase in tumor incidence, increased total number of lesions, and increased tumor size
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• decrease in the number of cilia per crypt in the colon
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/07/2024 MGI 6.23 |
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