Phenotypes associated with this allele

• Allele Symbol: Syt1^{tm1a(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4433781
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Syt1^tm1a(EUCOMM)Wtsi/Syt1^tm1a(EUCOMM)Wtsi	C57BL/6N-Syt1^tm1a(EUCOMM)Wtsi/Wtsi	MGI:5631602
ht2	Syt1^tm1a(EUCOMM)Wtsi/Syt1^+	C57BL/6N-Syt1^tm1a(EUCOMM)Wtsi/Wtsi	MGI:5706106

Genotype
MGI:5631602

hm1

• Allelic Composition: Syt1^{tm1a(EUCOMM)Wtsi}/Syt1^{tm1a(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-Syt1^{tm1a(EUCOMM)Wtsi}/Wtsi
• Cell Lines: EPD0214_1_H11

Data Sources

IMPC Data for Syt1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal ductus venosus valve morphology ( J:239583 )

DMDD

abnormal coronary sinus connection ( J:239583 )

DMDD

perimembraneous ventricular septal defect ( J:239583 )

DMDD

endocrine/exocrine glands

biliary cyst ( J:239583 )

DMDD

dilated bile duct ( J:239583 )

DMDD

adrenal gland cyst ( J:239583 )

DMDD

thyroid gland cyst ( J:239583 )

DMDD

growth/size/body

biliary cyst ( J:239583 )

DMDD

adrenal gland cyst ( J:239583 )

DMDD

thyroid gland cyst ( J:239583 )

DMDD

thoracoschisis ( J:239583 )

DMDD

liver/biliary system

biliary cyst ( J:239583 )

DMDD

dilated bile duct ( J:239583 )

DMDD

mortality/aging

preweaning lethality, incomplete penetrance ( J:211773 )

IMPC - WTSI

muscle

abnormal infrahyoid muscle connection ( J:239583 )

DMDD

normal phenotype

no abnormal phenotype detected ( J:239583 )

DMDD

respiratory system

abnormal infrahyoid muscle connection ( J:239583 )

DMDD

Genotype
MGI:5706106

ht2

• Allelic Composition: Syt1^{tm1a(EUCOMM)Wtsi}/Syt1⁺
• Genetic Background: C57BL/6N-Syt1^{tm1a(EUCOMM)Wtsi}/Wtsi
• Cell Lines: EPD0214_1_H11

Data Sources

IMPC Data for Syt1

growth/size/body

decreased lean body mass ( J:211773 )

♀

IMPC - WTSI

skeleton

decreased bone mineral content ( J:211773 )

♀

IMPC - WTSI