Phenotypes associated with this allele

• Allele Symbol: Mxra7^{tm1a(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4433751
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mxra7^tm1a(EUCOMM)Wtsi/Mxra7^tm1a(EUCOMM)Wtsi	involves: C57BL/6N	MGI:8209538

Genotype
MGI:8209538

hm1

• Allelic Composition: Mxra7^{tm1a(EUCOMM)Wtsi}/Mxra7^{tm1a(EUCOMM)Wtsi}
• Genetic Background: involves: C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal platelet physiology ( J:367057 )

• increased apoptosis

• however, no abnormality in tail bleeding time or platelet life span are detected

abnormal platelet activation ( J:367057 )

• decreased activation when stimulated with THB or ADP

increased platelet aggregation ( J:367057 )

• increased adhesion, aggregation and clot retraction

delayed wound healing ( J:334049 )

• at 28 days after punching holes in the ears the holes are still apparent unlike in wild-type mice

impaired wound healing ( J:334049 )

• at 7 and 28 days after injury regenerated tissues are shorter with fewer newly formed vessels and fewer infiltrated inflammatory cells

• at 19 days after injury collagen deposition is decreased

hematopoietic system

hematopoietic system phenotype ( J:367057 )

N • no significant difference in white or red blood cell counts

abnormal megakaryocyte morphology ( J:367057 )

• decrease in the percentage of polyploid megakaryocytes in the spleen but not in the bone marrow or peripheral blood

abnormal megakaryocyte differentiation ( J:367057 )

• decrease in the percentage of megakaryocytes differentiated from hematopoietic progenitor cells

• decrease in the percentage of polyploid cells in cultured megakaryocytes

decreased megakaryocyte cell number ( J:367057 )

• percentage and number of CD41+ megakaryocytes are decreased in bone marrow and splenocytes

• percentage of megakaryocytes are decreased in the peripheral blood

• however, no abnormalities are seen in other lineages of hemopoietic cells in the bone marrow, spleen, and peripheral blood

thrombocytopenia ( J:367057 )

• in the peripheral blood

abnormal platelet physiology ( J:367057 )

• increased apoptosis

• however, no abnormality in tail bleeding time or platelet life span are detected

abnormal platelet activation ( J:367057 )

• decreased activation when stimulated with THB or ADP

increased platelet aggregation ( J:367057 )

• increased adhesion, aggregation and clot retraction

cellular

abnormal cell adhesion ( J:334049 )

• isolated dermal fibroblasts display enhanced adhesion

abnormal megakaryocyte differentiation ( J:367057 )

• decrease in the percentage of megakaryocytes differentiated from hematopoietic progenitor cells

• decrease in the percentage of polyploid cells in cultured megakaryocytes

abnormal fibroblast physiology ( J:334049 )

• isolated dermal fibroblasts display enhanced adhesion and increased contractility

decreased fibroblast cell migration ( J:334049 )

• dermal fibroblast migration is impaired

decreased fibroblast proliferation ( J:334049 )

• isolated dermal fibroblasts show reduced proliferation potential