Phenotypes associated with this allele

• Allele Symbol: Stard7^{tm1a(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4433666
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Stard7^tm1a(EUCOMM)Wtsi/Stard7^tm1a(EUCOMM)Wtsi	involves: C57BL/6N	MGI:6105953
ht2	Stard7^tm1a(EUCOMM)Wtsi/Stard7^+	involves: C57BL/6N	MGI:6105954

Genotype
MGI:6105953

hm1

• Allelic Composition: Stard7^{tm1a(EUCOMM)Wtsi}/Stard7^{tm1a(EUCOMM)Wtsi}
• Genetic Background: involves: C57BL/6N
• Cell Lines: EPD0176_3_A10

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:242746 )

• survival rate decreased after E10

• surviving embryos have normal lifespan

Genotype
MGI:6105954

ht2

• Allelic Composition: Stard7^{tm1a(EUCOMM)Wtsi}/Stard7⁺
• Genetic Background: involves: C57BL/6N
• Cell Lines: EPD0176_3_A10

respiratory system

respiratory system phenotype ( J:242746 )

N • after sensitization by i.p. injection of OVA on days 0 and 7, followed by intratracheal challenge with OVA on days 18-21

lung inflammation ( J:242746 )

increased airway responsiveness ( J:242746 )

abnormal respiratory epithelial transmembrane transport ( J:242746 )

• increased epithelial barrier permeability

immune system

immune system phenotype ( J:242746 )

N • after sensitization and challenge with OVA

increased CD11b-high dendritic cell number ( J:242746 )

• in lung and lung-draining lymph nodes

increased susceptibility to type I hypersensitivity reaction ( J:242746 )

lung inflammation ( J:242746 )

dermatitis ( J:242746 )

• skin lesions, mainly on ears and back

• vigorous scratching

integument

integument phenotype ( J:242746 )

N • from 6-7 months after sensitization and challenge with OVA

dermatitis ( J:242746 )

• skin lesions, mainly on ears and back

• vigorous scratching

thick epidermis ( J:242746 )

• in skin lesions

hematopoietic system

hematopoietic system phenotype ( J:242746 )

N • after sensitization and challenge with OVA

increased CD11b-high dendritic cell number ( J:242746 )

• in lung and lung-draining lymph nodes

endocrine/exocrine glands

abnormal mucous gland morphology ( J:242746 )

• pulmonary mucous cell metaplasia after sensitization and challenge with OVA