Phenotypes associated with this allele

• Allele Symbol: Secisbp2^{tm1a(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4433050
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Secisbp2^tm1a(EUCOMM)Wtsi/Secisbp2^tm1a(EUCOMM)Wtsi	involves: C57BL/6N	MGI:5583956
ht2	Secisbp2^tm1a(EUCOMM)Wtsi/Secisbp2^+	involves: C57BL/6N	MGI:5583957
ht3	Secisbp2^tm1a(EUCOMM)Wtsi/Secisbp2^+	Not Specified	MGI:5450645

Genotype
MGI:5583956

hm1

• Allelic Composition: Secisbp2^{tm1a(EUCOMM)Wtsi}/Secisbp2^{tm1a(EUCOMM)Wtsi}
• Genetic Background: involves: C57BL/6N
• Cell Lines: EPD0052_2_C03

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:213080 )

• fewer than expected mice are present at E13.5

embryonic lethality between implantation and placentation, incomplete penetrance ( J:213080 )

• mice fail after implantation and arrest at TS7

preweaning lethality, complete penetrance ( J:213080 )

• no mice are present 3 weeks after birth

embryo

embryonic growth arrest ( J:213080 )

• at TS7

embryonic growth retardation ( J:213080 )

• at E8

growth/size/body

embryonic growth retardation ( J:213080 )

• at E8

Genotype
MGI:5583957

ht2

• Allelic Composition: Secisbp2^{tm1a(EUCOMM)Wtsi}/Secisbp2⁺
• Genetic Background: involves: C57BL/6N
• Cell Lines: EPD0052_2_C03

reproductive system

reproductive system phenotype ( J:213080 )

N • mice exhibit normal fertility

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:213080 )

N • mice exhibit normal levels of T4, T3 and TSH

abnormal selenium level ( J:213080 )

• reduced in the serum

Genotype
MGI:5450645

ht3

• Allelic Composition: Secisbp2^{tm1a(EUCOMM)Wtsi}/Secisbp2⁺
• Genetic Background: Not Specified
• Cell Lines: EPD0052_2_C03

Data Sources

IMPC Data for Secisbp2

hematopoietic system

increased NK cell number ( J:165965 )

IMPC - HAR

immune system

increased NK cell number ( J:165965 )

IMPC - HAR