Phenotypes associated with this allele

• Allele Symbol: Prmt3^{tm1a(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4433008
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Prmt3^tm1a(EUCOMM)Wtsi/Prmt3^tm1a(EUCOMM)Wtsi	B6Brd;B6Dnk;B6N-Tyr^c-Brd Prmt3^tm1a(EUCOMM)Wtsi/Wtsi	MGI:6272808
hm2	Prmt3^tm1a(EUCOMM)Wtsi/Prmt3^tm1a(EUCOMM)Wtsi	involves: C57BL/6 * C57BL/6N	MGI:5790994
ht3	Prmt3^tm1a(EUCOMM)Wtsi/Prmt3^+	B6JTyr;B6N-Prmt3^tm1a(EUCOMM)Wtsi/Wtsi	MGI:5781709

Genotype
MGI:6272808

hm1

• Allelic Composition: Prmt3^{tm1a(EUCOMM)Wtsi}/Prmt3^{tm1a(EUCOMM)Wtsi}
• Genetic Background: B6Brd;B6Dnk;B6N-Tyr^c-Brd Prmt3^{tm1a(EUCOMM)Wtsi}/Wtsi
• Cell Lines: EPD0070_5_D05

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:232539 )

integument

abnormal hypodermis fat layer morphology ( J:232539 )

♀ • at necropsy (16.4 weeks of age), mice fed a high-fat diet show granulomatous steatitis

adipose tissue

abnormal hypodermis fat layer morphology ( J:232539 )

♀ • at necropsy (16.4 weeks of age), mice fed a high-fat diet show granulomatous steatitis

Genotype
MGI:5790994

hm2

• Allelic Composition: Prmt3^{tm1a(EUCOMM)Wtsi}/Prmt3^{tm1a(EUCOMM)Wtsi}
• Genetic Background: involves: C57BL/6 * C57BL/6N
• Cell Lines: EPD0070_5_D05

growth/size/body

decreased body weight ( J:213427 )

decreased body length ( J:213427 )

hematopoietic system

increased T cell number ( J:213427 )

increased CD4-positive, alpha-beta T cell number ( J:213427 )

increased CD8-positive, alpha-beta T cell number ( J:213427 )

homeostasis/metabolism

decreased respiratory quotient ( J:213427 )

immune system

increased T cell number ( J:213427 )

increased CD4-positive, alpha-beta T cell number ( J:213427 )

increased CD8-positive, alpha-beta T cell number ( J:213427 )

increased incidence of corneal inflammation ( J:213427 )

• keratitis

mortality/aging

lethality, incomplete penetrance ( J:213427 )

decreased survivor rate ( J:213427 )

postnatal lethality, incomplete penetrance ( J:213427 )

nervous system

hydrocephaly ( J:213427 )

skeleton

decreased bone mineral content ( J:213427 )

decreased bone mineral density ( J:213427 )

vision/eye

increased incidence of corneal inflammation ( J:213427 )

• keratitis

abnormal cornea morphology ( J:213427 )

cornea opacity ( J:213427 )

cataract ( J:213427 )

narrow eye opening ( J:213427 )

Genotype
MGI:5781709

ht3

• Allelic Composition: Prmt3^{tm1a(EUCOMM)Wtsi}/Prmt3⁺
• Genetic Background: B6JTyr;B6N-Prmt3^{tm1a(EUCOMM)Wtsi}/Wtsi
• Cell Lines: EPD0070_5_D05

Data Sources

IMPC Data for Prmt3

skeleton

increased sacral vertebrae number ( J:175295 )

♂

IMPC - WTSI