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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Plxna2tm1a(EUCOMM)Wtsi
targeted mutation 1a, Wellcome Trust Sanger Institute
MGI:4432861
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Plxna2tm1a(EUCOMM)Wtsi/Plxna2tm1a(EUCOMM)Wtsi C57BL/6N-Plxna2tm1a(EUCOMM)Wtsi/Wtsi MGI:6480551
cn2
Chattm2(cre)Lowl/Chat+
Plxna2tm1a(EUCOMM)Wtsi/Plxna2tm1Hfu
involves: 129S6/SvEvTac * C57BL/6N * CBA/JNCrlj MGI:5562536


Genotype
MGI:6480551
hm1
Allelic
Composition
Plxna2tm1a(EUCOMM)Wtsi/Plxna2tm1a(EUCOMM)Wtsi
Genetic
Background
C57BL/6N-Plxna2tm1a(EUCOMM)Wtsi/Wtsi
Cell Lines EPD0418_6_A12
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plxna2tm1a(EUCOMM)Wtsi mutation (2 available); any Plxna2 mutation (127 available)
Data Sources
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system




Genotype
MGI:5562536
cn2
Allelic
Composition
Chattm2(cre)Lowl/Chat+
Plxna2tm1a(EUCOMM)Wtsi/Plxna2tm1Hfu
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6N * CBA/JNCrlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chattm2(cre)Lowl mutation (4 available); any Chat mutation (57 available)
Plxna2tm1a(EUCOMM)Wtsi mutation (2 available); any Plxna2 mutation (127 available)
Plxna2tm1Hfu mutation (1 available); any Plxna2 mutation (127 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• the starburst amacrine cell (SAC) processes that normally stratify in 2 discrete inner plexiform laminae (S2 and S4) fail to completely segregate from each other
• disruption of the dendritic plexus organization of On but not Off SACs
• the starburst amacrine cell (SAC) processes that normally stratify in 2 discrete inner plexiform laminae (S2 and S4) fail to completely segregate from each other

nervous system
• the starburst amacrine cell (SAC) processes that normally stratify in 2 discrete inner plexiform laminae (S2 and S4) fail to completely segregate from each other
• disruption of the dendritic plexus organization of On but not Off SACs
• the starburst amacrine cell (SAC) processes that normally stratify in 2 discrete inner plexiform laminae (S2 and S4) fail to completely segregate from each other
• disruption of the dendritic plexus organization of On but not Off SACs





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory