Phenotypes associated with this allele

• Allele Symbol: Arvcf^{tm1e(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1e, Wellcome Trust Sanger Institute
• Allele ID: MGI:4432634
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Arvcf^tm1e(EUCOMM)Wtsi/Arvcf^tm1e(EUCOMM)Wtsi	C57BL/6N-Arvcf^tm1e(EUCOMM)Wtsi/Ieg	MGI:5797381
hm2	Arvcf^tm1e(EUCOMM)Wtsi/Arvcf^tm1e(EUCOMM)Wtsi	C57BL/6NTac-Arvcf^tm1e(EUCOMM)Wtsi/Ieg	MGI:8176112
ht3	Arvcf^tm1e(EUCOMM)Wtsi/Arvcf^+	C57BL/6NTac-Arvcf^tm1e(EUCOMM)Wtsi/Ieg	MGI:8176111

Genotype
MGI:5797381

hm1

• Allelic Composition: Arvcf^{tm1e(EUCOMM)Wtsi}/Arvcf^{tm1e(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-Arvcf^{tm1e(EUCOMM)Wtsi}/Ieg
• Cell Lines: EPD0102_1_D06

Data Sources

IMPC Data for Arvcf

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal gait ( J:211773 )

♀

IMPC - WTSI

homeostasis/metabolism

increased circulating alkaline phosphatase level ( J:211773 )

♀

IMPC - WTSI

vision/eye

abnormal lens morphology ( J:211773 )

♂

IMPC - WTSI

cataract ( J:211773 )

♂

IMPC - WTSI

Genotype
MGI:8176112

hm2

• Allelic Composition: Arvcf^{tm1e(EUCOMM)Wtsi}/Arvcf^{tm1e(EUCOMM)Wtsi}
• Genetic Background: C57BL/6NTac-Arvcf^{tm1e(EUCOMM)Wtsi}/Ieg
• Cell Lines: EPD0102_1_D06

Data Sources

IMPC Data for Arvcf

behavior/neurological

tremors ( J:211773 )

IMPC - HMGU

decreased grip strength ( J:211773 )

IMPC - HMGU

abnormal gait ( J:211773 )

IMPC - HMGU

nervous system

abnormal optic disk morphology ( J:211773 )

IMPC - HMGU

skeleton

abnormal bone structure ( J:211773 )

♀

IMPC - HMGU

decreased bone mineral density ( J:211773 )

IMPC - HMGU

vision/eye

abnormal optic disk morphology ( J:211773 )

IMPC - HMGU

abnormal lens morphology ( J:211773 )

IMPC - HMGU

cataract ( J:211773 )

IMPC - HMGU

abnormal retina morphology ( J:211773 )

IMPC - HMGU

decreased total retina thickness ( J:211773 )

IMPC - HMGU

Genotype
MGI:8176111

ht3

• Allelic Composition: Arvcf^{tm1e(EUCOMM)Wtsi}/Arvcf⁺
• Genetic Background: C57BL/6NTac-Arvcf^{tm1e(EUCOMM)Wtsi}/Ieg
• Cell Lines: EPD0102_1_D06

Data Sources

IMPC Data for Arvcf

endocrine/exocrine glands

absent testes ( J:211773 )

♂

IMPC - HMGU

hematopoietic system

increased mean platelet volume ( J:211773 )

IMPC - HMGU

reproductive system

absent testes ( J:211773 )

♂

IMPC - HMGU