Phenotypes associated with this allele

• Allele Symbol: Ufl1^{tm1a(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4432479
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ufl1^tm1a(EUCOMM)Wtsi/Ufl1^tm1a(EUCOMM)Wtsi	involves: C57BL/6N	MGI:5825317
ht2	Ufl1^tm1a(EUCOMM)Wtsi/Ufl1^+	C57BL/6N-Ufl1^tm1a(EUCOMM)Wtsi/Wtsi	MGI:5781789

Genotype
MGI:5825317

hm1

• Allelic Composition: Ufl1^{tm1a(EUCOMM)Wtsi}/Ufl1^{tm1a(EUCOMM)Wtsi}
• Genetic Background: involves: C57BL/6N
• Cell Lines: EPD0169_3_F12

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:238253 )

• some mice die as early as E10.5

• no mice are present at E12.5

hematopoietic system

anemia ( J:238253 )

• at E11.5

decreased erythroid progenitor cell number ( J:238253 )

• reduced CFU-E and BFU-E from E11.5 fetal livers

increased nucleated erythrocyte cell number ( J:238253 )

• at E11.5

growth/size/body

decreased embryo size ( J:238253 )

• at E11.5

liver/biliary system

small liver ( J:238253 )

• at E11.5

embryo

decreased embryo size ( J:238253 )

• at E11.5

Genotype
MGI:5781789

ht2

• Allelic Composition: Ufl1^{tm1a(EUCOMM)Wtsi}/Ufl1⁺
• Genetic Background: C57BL/6N-Ufl1^{tm1a(EUCOMM)Wtsi}/Wtsi
• Cell Lines: EPD0169_3_F12

Data Sources

IMPC Data for Ufl1

adipose tissue

decreased total body fat amount ( J:175295 )

IMPC - WTSI

growth/size/body

decreased body weight ( J:175295 )

IMPC - WTSI

homeostasis/metabolism

decreased circulating alanine transaminase level ( J:175295 )

IMPC - WTSI

decreased circulating aspartate transaminase level ( J:175295 )

IMPC - WTSI