Phenotypes associated with this allele

• Allele Symbol: Stx8^{tm2a(EUCOMM)Wtsi}
• Allele Name: targeted mutation 2a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4432376
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Stx8^tm2a(EUCOMM)Wtsi/Stx8^tm2a(EUCOMM)Wtsi	B6JTyr;B6N-Stx8^tm2a(EUCOMM)Wtsi/Wtsi	MGI:5781770
hm2	Stx8^tm2a(EUCOMM)Wtsi/Stx8^tm2a(EUCOMM)Wtsi	involves: C57BL/6 * C57BL/6N	MGI:5790630
hm3	Stx8^tm2a(EUCOMM)Wtsi/Stx8^tm2a(EUCOMM)Wtsi	involves: C57BL/6N	MGI:5708056

Genotype
MGI:5781770

hm1

• Allelic Composition: Stx8^{tm2a(EUCOMM)Wtsi}/Stx8^{tm2a(EUCOMM)Wtsi}
• Genetic Background: B6JTyr;B6N-Stx8^{tm2a(EUCOMM)Wtsi}/Wtsi
• Cell Lines: EPD0038_2_A04

Data Sources

IMPC Data for Stx8

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

decreased lumbar vertebrae number ( J:175295 )

♀

IMPC - WTSI

increased sacral vertebrae number ( J:175295 )

♀

IMPC - WTSI

Genotype
MGI:5790630

hm2

• Allelic Composition: Stx8^{tm2a(EUCOMM)Wtsi}/Stx8^{tm2a(EUCOMM)Wtsi}
• Genetic Background: involves: C57BL/6 * C57BL/6N
• Cell Lines: EPD0038_2_A04

normal phenotype

no abnormal phenotype detected ( J:213427 )

Genotype
MGI:5708056

hm3

• Allelic Composition: Stx8^{tm2a(EUCOMM)Wtsi}/Stx8^{tm2a(EUCOMM)Wtsi}
• Genetic Background: involves: C57BL/6N

hematopoietic system

hematopoietic system phenotype ( J:218388 )

N • blood cell counts are normal and platelets are of normal size

N • secretion by platelet alpha granules and lysosomes are normal

abnormal platelet physiology ( J:218388 )

decreased platelet aggregation ( J:218388 )

• defect in platelet aggregation due to defect in dense granule secretion

abnormal platelet dense granule physiology ( J:218388 )

• less ATP is released by platelets although the dense granule content is normal

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:218388 )

N • normal tail bleeding time

abnormal platelet physiology ( J:218388 )

decreased platelet aggregation ( J:218388 )

• defect in platelet aggregation due to defect in dense granule secretion

abnormal platelet dense granule physiology ( J:218388 )

• less ATP is released by platelets although the dense granule content is normal

abnormal thrombosis ( J:218388 )

• normal thrombus formation

• thrombi are less stable than those of controls and more likely to embolize