Analysis Tools
skeleton
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IMPC - WTSI
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IMPC - WTSI
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Allele Symbol Allele Name Allele ID |
Stx8tm2a(EUCOMM)Wtsi targeted mutation 2a, Wellcome Trust Sanger Institute MGI:4432376 |
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| Summary |
3 genotypes
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Data Sources
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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IMPC - WTSI
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IMPC - WTSI
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• blood cell counts are normal and platelets are of normal size
• secretion by platelet alpha granules and lysosomes are normal
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• defect in platelet aggregation due to defect in dense granule secretion
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• less ATP is released by platelets although the dense granule content is normal
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| N |
• normal tail bleeding time
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• defect in platelet aggregation due to defect in dense granule secretion
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• less ATP is released by platelets although the dense granule content is normal
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• normal thrombus formation
• thrombi are less stable than those of controls and more likely to embolize
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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