All Phenotypes Tcf4<tm1a(EUCOMM)Wtsi> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tcf4^{tm1a(EUCOMM)Wtsi}
targeted mutation 1a, Wellcome Trust Sanger Institute
MGI:4432303

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tcf4^{tm1a(EUCOMM)Wtsi}/Tcf4^{tm1a(EUCOMM)Wtsi}	C57BL/6N-Tcf4^{tm1a(EUCOMM)Wtsi}/Wtsi	MGI:5631609
ht2	Tcf4^{tm1a(EUCOMM)Wtsi}/Tcf4⁺	C57BL/6N-Tcf4^{tm1a(EUCOMM)Wtsi}/Wtsi	MGI:5706107
ht3	Tcf4^{tm1a(EUCOMM)Wtsi}/Tcf4⁺	involves: C57BL/6N	MGI:6479897

Allelic Composition	Tcf4^{tm1a(EUCOMM)Wtsi}/Tcf4^{tm1a(EUCOMM)Wtsi}
Genetic Background	C57BL/6N-Tcf4^{tm1a(EUCOMM)Wtsi}/Wtsi
Cell Lines	EPD0103_3_A07

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf4^{tm1a(EUCOMM)Wtsi} mutation (2 available); any Tcf4 mutation (63 available)

Data Sources

IMPC Data for Tcf4

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:211773 )

IMPC - WTSI

Allelic Composition	Tcf4^{tm1a(EUCOMM)Wtsi}/Tcf4⁺
Genetic Background	C57BL/6N-Tcf4^{tm1a(EUCOMM)Wtsi}/Wtsi
Cell Lines	EPD0103_3_A07

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf4^{tm1a(EUCOMM)Wtsi} mutation (2 available); any Tcf4 mutation (63 available)

Data Sources

IMPC Data for Tcf4

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal retina morphology ( J:211773 )

IMPC - WTSI

Allelic Composition	Tcf4^{tm1a(EUCOMM)Wtsi}/Tcf4⁺
Genetic Background	involves: C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf4^{tm1a(EUCOMM)Wtsi} mutation (2 available); any Tcf4 mutation (63 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal corpus callosum morphology ( J:265025 )

• mice show agenesis of the splenium of the corpus callosum

abnormal dentate gyrus morphology ( J:265025 )

• dentate gyrus volume is decreased

decreased hippocampus volume ( J:265025 )

• reduction in hippocampal volume

thin cerebral cortex ( J:265025 )

• cortical thickness is reduced in all analyzed areas

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Pitt-Hopkins syndrome		DOID:0060488	OMIM:610954	J:265025

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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