Phenotypes associated with this allele

• Allele Symbol: Dmxl2^{tm1a(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4432280
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dmxl2^tm1a(EUCOMM)Wtsi/Dmxl2^tm1a(EUCOMM)Wtsi	C57BL/6N-A^tm1Brd Dmxl2^tm1a(EUCOMM)Wtsi/WtsiH	MGI:5631051
hm2	Dmxl2^tm1a(EUCOMM)Wtsi/Dmxl2^tm1a(EUCOMM)Wtsi	involves: C57BL/6N	MGI:5805373
ht3	Dmxl2^tm1a(EUCOMM)Wtsi/Dmxl2^+	C57BL/6N-A^tm1Brd Dmxl2^tm1a(EUCOMM)Wtsi/WtsiH	MGI:5705987
ht4	Dmxl2^tm1a(EUCOMM)Wtsi/Dmxl2^+	involves: C57BL/6N	MGI:5805374

Genotype
MGI:5631051

hm1

• Allelic Composition: Dmxl2^{tm1a(EUCOMM)Wtsi}/Dmxl2^{tm1a(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-A^tm1Brd Dmxl2^{tm1a(EUCOMM)Wtsi}/WtsiH
• Cell Lines: EPD0431_3_A05

Data Sources

IMPC Data for Dmxl2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal vertebral artery morphology ( J:239583 )

DMDD

abnormal ductus venosus valve morphology ( J:239583 )

DMDD

endocrine/exocrine glands

multiple persisting craniopharyngeal ducts ( J:239583 )

DMDD

immune system

blood in lymph vessels ( J:239583 )

DMDD

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - WTSI

neoplasm

embryo tumor ( J:239583 )

DMDD

nervous system

multiple persisting craniopharyngeal ducts ( J:239583 )

DMDD

normal phenotype

no abnormal phenotype detected ( J:239583 )

DMDD

Genotype
MGI:5805373

hm2

• Allelic Composition: Dmxl2^{tm1a(EUCOMM)Wtsi}/Dmxl2^{tm1a(EUCOMM)Wtsi}
• Genetic Background: involves: C57BL/6N
• Cell Lines: EPD0431_3_E07

mortality/aging

prenatal lethality, complete penetrance ( J:217623 )

• heterozygous intercrosses fail to produce viable homozygous offspring

Genotype
MGI:5705987

ht3

• Allelic Composition: Dmxl2^{tm1a(EUCOMM)Wtsi}/Dmxl2⁺
• Genetic Background: C57BL/6N-A^tm1Brd Dmxl2^{tm1a(EUCOMM)Wtsi}/WtsiH
• Cell Lines: EPD0431_3_A05

Data Sources

IMPC Data for Dmxl2

adipose tissue

increased total body fat amount ( J:211773 )

♀

IMPC - WTSI

growth/size/body

decreased lean body mass ( J:211773 )

♀

IMPC - WTSI

homeostasis/metabolism

decreased circulating cholesterol level ( J:211773 )

♂

IMPC - WTSI

skeleton

decreased bone mineral content ( J:211773 )

♀

IMPC - WTSI

Genotype
MGI:5805374

ht4

• Allelic Composition: Dmxl2^{tm1a(EUCOMM)Wtsi}/Dmxl2⁺
• Genetic Background: involves: C57BL/6N
• Cell Lines: EPD0431_3_E07

normal phenotype

no abnormal phenotype detected ( J:217623 )

• heterozygotes exhibit no overt morphological or growth deficit phenotype and are fertile

• although vaginal opening (VO) is slightly delayed and a longer time between VO and first estrus is observed, these differences are not significant