Phenotypes associated with this allele

• Allele Symbol: Tg(Bglap2-Phex)1Ldq
• Allele Name: transgene insertion 1, L Darryl Quarles
• Allele ID: MGI:4431210
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Phex^Hyp/Phex^+ Tg(Bglap2-Phex)1Ldq/?	involves: C57BL/6J	MGI:4431220
tg2	Tg(Bglap2-Phex)1Ldq/?	involves: C57BL/6J	MGI:4431215

Genotype
MGI:4431220

cx1

• Allelic Composition: Phex^Hyp/Phex⁺; Tg(Bglap2-Phex)1Ldq/?
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased circulating phosphate level ( J:74324 )

♀ • despite increased Phex expression in osteoblasts these mice still have the diminished serum phosphate of hypophosphatemia mutants

skeleton

decreased bone mass ( J:74324 )

♀

abnormal bone mineralization ( J:74324 )

♀ • despite increased Phex expression in osteoblasts these mice have the same skeletal defects of hypophosphatemia mice including reduced bone mineral density, smaller than normal caudal vertebrae, increased widening and irregularity of growth plates, rickets and osteomalacia

osteomalacia ( J:74324 )

♀

rickets ( J:74324 )

♀

Genotype
MGI:4431215

tg2

• Allelic Composition: Tg(Bglap2-Phex)1Ldq/?
• Genetic Background: involves: C57BL/6J

normal phenotype

no abnormal phenotype detected ( J:74324 )

• despite bone-specific over-expression of Phex shown to cause increased endopeptidase activity, these mice are indistinguishabe from non-transgenic controls including normal serum phosphate levels and normal bone mineralization, osteoid thickness, and bone mass