Phenotypes associated with this allele

• Allele Symbol: Tg(tetO-Bnip3l)1Gwd
• Allele Name: transgene insertion 1, Gerald W Dorn II
• Allele ID: MGI:4430395
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Tg(Myh6-Gnaq)#Gwd/0 Tg(Myh6-tTA)55Rbns/0 Tg(tetO-Bnip3l)1Gwd/0	involves: FVB/N	MGI:4430402
cx2	Tg(Myh6-tTA)55Rbns/0 Tg(tetO-Bnip3l)1Gwd/0	involves: FVB/N	MGI:4430403

Genotype
MGI:4430402

cx1

• Allelic Composition: Tg(Myh6-Gnaq)#Gwd/0; Tg(Myh6-tTA)55Rbns/0; Tg(tetO-Bnip3l)1Gwd/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:145086 )

• all mice die between 6 and 8 weeks after birth

cardiovascular system

abnormal heart ventricle morphology ( J:145086 )

• mice exhibit ventricular remodeling as measured by the ratio of the ventricular radius to wall thickness unlike in wild-type mice

decreased cardiac muscle contractility ( J:145086 )

• drastically

increased cardiomyocyte apoptosis ( J:145086 )

muscle

decreased cardiac muscle contractility ( J:145086 )

• drastically

increased cardiomyocyte apoptosis ( J:145086 )

cellular

increased cardiomyocyte apoptosis ( J:145086 )

Genotype
MGI:4430403

cx2

• Allelic Composition: Tg(Myh6-tTA)55Rbns/0; Tg(tetO-Bnip3l)1Gwd/0
• Genetic Background: involves: FVB/N

cardiovascular system

cardiovascular system phenotype ( J:145086 )

N • mice do not exhibit ventricular remodeling

decreased cardiac muscle contractility ( J:145086 )

• over time

increased cardiomyocyte apoptosis ( J:145086 )

muscle

decreased cardiac muscle contractility ( J:145086 )

• over time

increased cardiomyocyte apoptosis ( J:145086 )

cellular

increased cardiomyocyte apoptosis ( J:145086 )