Phenotypes associated with this allele

• Allele Symbol: Tg(Myh6-Gnaq)#Gwd
• Allele Name: transgene insertion, Gerald W Dorn II
• Allele ID: MGI:4430394
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Bnip3l^tm1.1Gwd/Bnip3l^tm1.1Gwd Tg(Myh6-Gnaq)#Gwd/0	involves: 129 * FVB/N	MGI:4430400
cx2	Tg(Myh6-Gnaq)#Gwd/0 Tg(Myh6-tTA)55Rbns/0 Tg(tetO-Bnip3l)1Gwd/0	involves: FVB/N	MGI:4430402
tg3	Tg(Myh6-Gnaq)#Gwd/0	involves: FVB/N	MGI:4430401

Genotype
MGI:4430400

cx1

• Allelic Composition: Bnip3l^tm1.1Gwd/Bnip3l^tm1.1Gwd; Tg(Myh6-Gnaq)#Gwd/0
• Genetic Background: involves: 129 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:145086 )

• mice exhibit premature death with wild-type mice that is not as severe as in Tg(Myh6-Gnaq)Gwd mice

cardiovascular system

cardiovascular system phenotype ( J:145086 )

N • mice do not exhibit ventricular remodeling unlike Tg(Myh6-Gnaq)Gwd mice

enlarged heart ( J:145086 )

• not as severe as in Tg(Myh6-Gnaq)Gwd mice

dilated heart ( J:145086 )

• not as severe as in Tg(Myh6-Gnaq)Gwd mice

decreased cardiac muscle contractility ( J:145086 )

• not as severe as in Tg(Myh6-Gnaq)Gwd mice

increased cardiomyocyte apoptosis ( J:145086 )

• not as severe as in Tg(Myh6-Gnaq)Gwd mice

muscle

decreased cardiac muscle contractility ( J:145086 )

• not as severe as in Tg(Myh6-Gnaq)Gwd mice

increased cardiomyocyte apoptosis ( J:145086 )

• not as severe as in Tg(Myh6-Gnaq)Gwd mice

cellular

increased cardiomyocyte apoptosis ( J:145086 )

• not as severe as in Tg(Myh6-Gnaq)Gwd mice

growth/size/body

enlarged heart ( J:145086 )

• not as severe as in Tg(Myh6-Gnaq)Gwd mice

Genotype
MGI:4430402

cx2

• Allelic Composition: Tg(Myh6-Gnaq)#Gwd/0; Tg(Myh6-tTA)55Rbns/0; Tg(tetO-Bnip3l)1Gwd/0
• Genetic Background: involves: FVB/N

mortality/aging

premature death ( J:145086 )

• all mice die between 6 and 8 weeks after birth

cardiovascular system

abnormal heart ventricle morphology ( J:145086 )

• mice exhibit ventricular remodeling as measured by the ratio of the ventricular radius to wall thickness unlike in wild-type mice

decreased cardiac muscle contractility ( J:145086 )

• drastically

increased cardiomyocyte apoptosis ( J:145086 )

muscle

decreased cardiac muscle contractility ( J:145086 )

• drastically

increased cardiomyocyte apoptosis ( J:145086 )

cellular

increased cardiomyocyte apoptosis ( J:145086 )

Genotype
MGI:4430401

tg3

• Allelic Composition: Tg(Myh6-Gnaq)#Gwd/0
• Genetic Background: involves: FVB/N

mortality/aging

postnatal lethality ( J:145086 )

• postpartum, 50% of mice die of heart failure unlike wild-type mice

• however, neonatal survival is normal

cardiovascular system

enlarged heart ( J:145086 )

• postpartum

abnormal heart ventricle morphology ( J:145086 )

• mice exhibit mild ventricular remodeling as measured by the ratio of the ventricular radius to wall thickness unlike in wild-type mice

abnormal heart left ventricle morphology ( J:145086 )

• postpartum, mice exhibit left ventricle remodeling unlike wild-type mice

dilated heart ( J:145086 )

• postpartum

decreased cardiac muscle contractility ( J:145086 )

• postpartum, fractional shortening is decreased 50% compared to in wild-type mice

increased cardiomyocyte apoptosis ( J:145086 )

• postpartum but not neonatally

congestive heart failure ( J:145086 )

• postpartum, 50% of mice die of heart failure unlike wild-type mice

muscle

decreased cardiac muscle contractility ( J:145086 )

• postpartum, fractional shortening is decreased 50% compared to in wild-type mice

increased cardiomyocyte apoptosis ( J:145086 )

• postpartum but not neonatally

cellular

increased cardiomyocyte apoptosis ( J:145086 )

• postpartum but not neonatally

growth/size/body

enlarged heart ( J:145086 )

• postpartum