All Phenotypes Gfi1<tm1(cre)Gan> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gfi1^tm1(cre)Gan/Gfi1⁺ Rfx3^tm2Wrth/Rfx3^tm2Wrth	involves: 129 * 129S7/SvEvBrd	MGI:5907529
cn2	Gfi1^tm1(cre)Gan/Gfi1⁺ Rfx1^tm1.1Wrth/Rfx1^tm1.1Wrth Rfx3^tm2Wrth/Rfx3^tm2Wrth	involves: 129 * 129S7/SvEvBrd	MGI:5907531
cn3	Bmp2^tm1Brd/Bmp2^tm1.1Mis Gfi1^tm1(cre)Gan/Gfi1⁺	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J	MGI:4430834
cn4	Pkhd1l1^{tm2c(EUCOMM)Hmgu}/Pkhd1l1^{tm2c(EUCOMM)Hmgu} Gfi1^tm1(cre)Gan/Gfi1⁺	involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6N	MGI:6379249
cn5	Rest^tm1.1Bban/Rest⁺ Gfi1^tm1(cre)Gan/Gfi1⁺	involves: 129S4/SvJaeSor * 129S7/SvEvBrd * FVB/N	MGI:6378689
cn6	Gfi1^tm1(cre)Gan/Gfi1⁺ Rfx1^tm1.1Wrth/Rfx1^tm1.1Wrth	involves: 129S7/SvEvBrd	MGI:5907530

Allelic Composition	Gfi1^tm1(cre)Gan/Gfi1⁺ Rfx3^tm2Wrth/Rfx3^tm2Wrth
Genetic Background	involves: 129 * 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gfi1^tm1(cre)Gan mutation (0 available); any Gfi1 mutation (31 available)
Rfx3^tm2Wrth mutation (0 available); any Rfx3 mutation (68 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:227631 )

N	• normal hearing thresholds at 3 months of age

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hearing/vestibular/ear

abnormal inner hair cell kinocilium morphology ( J:227631 )

• inner hair cells retain kinocilia at P15 unlike in wild-type cells where kinocilia are retracted by this time

decreased cochlear outer hair cell number ( J:227631 )

• widespread loss of outer hair cells by P15

absent cochlear outer hair cells ( J:227631 )

• by P90

cochlear inner hair cell degeneration ( J:227631 )

• progressive degeneration associated with sporadic fusion of stereocilia on some of the remaining bundles by P90

abnormal cochlear outer hair cell physiology ( J:227631 )

• increase in expression of pro-apoptotic factors in outer hair cells at P12 and P15

impaired hearing ( J:227631 )

• rapid progressive hearing loss beginning at P22 with no measurable hearing by 3 months of age

deafness ( J:227631 )

• no measurable hearing by 3 months of age

nervous system

abnormal inner hair cell kinocilium morphology ( J:227631 )

• inner hair cells retain kinocilia at P15 unlike in wild-type cells where kinocilia are retracted by this time

decreased cochlear outer hair cell number ( J:227631 )

• widespread loss of outer hair cells by P15

absent cochlear outer hair cells ( J:227631 )

• by P90

cochlear inner hair cell degeneration ( J:227631 )

• progressive degeneration associated with sporadic fusion of stereocilia on some of the remaining bundles by P90

abnormal cochlear outer hair cell physiology ( J:227631 )

• increase in expression of pro-apoptotic factors in outer hair cells at P12 and P15

cellular

abnormal inner hair cell kinocilium morphology ( J:227631 )

• inner hair cells retain kinocilia at P15 unlike in wild-type cells where kinocilia are retracted by this time

increased apoptosis ( J:227631 )

• increase in expression of pro-apoptotic factors in outer hair cells at P12 and P15

Allelic Composition	Bmp2^tm1Brd/Bmp2^tm1.1Mis Gfi1^tm1(cre)Gan/Gfi1⁺
Genetic Background	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp2^tm1.1Mis mutation (0 available); any Bmp2 mutation (26 available)
Bmp2^tm1Brd mutation (0 available); any Bmp2 mutation (26 available)
Gfi1^tm1(cre)Gan mutation (0 available); any Gfi1 mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hearing/vestibular/ear

increased or absent threshold for auditory brainstem response ( J:156945 )

• a 6.5 dB shift in threshold is detected at 16kHz in 3-6 month-old mice compared to controls; at 9-10 months, hearing thresholds are comparable to controls

Allelic Composition	Pkhd1l1^{tm2c(EUCOMM)Hmgu}/Pkhd1l1^{tm2c(EUCOMM)Hmgu} Gfi1^tm1(cre)Gan/Gfi1⁺
Genetic Background	involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gfi1^tm1(cre)Gan mutation (0 available); any Gfi1 mutation (31 available)
Pkhd1l1^{tm2c(EUCOMM)Hmgu} mutation (0 available); any Pkhd1l1 mutation (239 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:280240 )

• no viable homozygotes are produced

Allelic Composition	Rest^tm1.1Bban/Rest⁺ Gfi1^tm1(cre)Gan/Gfi1⁺
Genetic Background	involves: 129S4/SvJaeSor * 129S7/SvEvBrd * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gfi1^tm1(cre)Gan mutation (0 available); any Gfi1 mutation (31 available)
Rest^tm1.1Bban mutation (0 available); any Rest mutation (95 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hearing/vestibular/ear

cochlear inner hair cell degeneration ( J:265659 )

deafness ( J:265659 )

nervous system

cochlear inner hair cell degeneration ( J:265659 )

Allelic Composition	Gfi1^tm1(cre)Gan/Gfi1⁺ Rfx1^tm1.1Wrth/Rfx1^tm1.1Wrth
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gfi1^tm1(cre)Gan mutation (0 available); any Gfi1 mutation (31 available)
Rfx1^tm1.1Wrth mutation (0 available); any Rfx1 mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:227631 )

N	• normal hearing thresholds at 3 months of age

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