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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Foxp3tm7.2Ayr
targeted mutation 7.2, Alexander Y Rudensky
MGI:4430234
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Foxp3tm7.2Ayr/Foxp3tm7.2Ayr involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ MGI:4430235
ht2
 		Foxp3tm7.2Ayr/Foxp3+ involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ MGI:4430237


Genotype
MGI:4430235
hm1
Allelic
Composition		 Foxp3tm7.2Ayr/Foxp3tm7.2Ayr
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxp3tm7.2Ayr mutation (0 available); any Foxp3 mutation (55 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal regulatory T cell morphology ( J:156942 )
• numbers of proliferating Ki67+ Foxp3+ thymocytes and peripheral cells are increased compared to control
decreased regulatory T cell number ( J:156942 )
• about a 5-fold decrease in the frequency of Foxp3+ CD4 single-positive thymocytes but the amount of Foxp3 on a per cell basis is unaffected
• in spleen and thymus peripheral Treg cell frequencies are moderately diminished

immune system
abnormal regulatory T cell morphology ( J:156942 )
• numbers of proliferating Ki67+ Foxp3+ thymocytes and peripheral cells are increased compared to control
decreased regulatory T cell number ( J:156942 )
• about a 5-fold decrease in the frequency of Foxp3+ CD4 single-positive thymocytes but the amount of Foxp3 on a per cell basis is unaffected
• in spleen and thymus peripheral Treg cell frequencies are moderately diminished




Genotype
MGI:4430237
ht2
Allelic
Composition		 Foxp3tm7.2Ayr/Foxp3+
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxp3tm7.2Ayr mutation (0 available); any Foxp3 mutation (55 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased regulatory T cell number ( J:156942 )
• marked decrease in T reg cells expressing the mutant allele in females

immune system
decreased regulatory T cell number ( J:156942 )
• marked decrease in T reg cells expressing the mutant allele in females




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory