Phenotypes associated with this allele

• Allele Symbol: Foxp3^tm5.2Ayr
• Allele Name: targeted mutation 5.2, Alexander Y Rudensky
• Allele ID: MGI:4430232
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Foxp3^tm5.2Ayr/Foxp3^tm5.2Ayr	involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ	MGI:4430239

Genotype
MGI:4430239

hm1

• Allelic Composition: Foxp3^tm5.2Ayr/Foxp3^tm5.2Ayr
• Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal T cell differentiation ( J:156942 )

♀ • impairment in the ability of CD4 TN cells to generate iTreg cells, most prominently in the gut associated lymphoid tissues in a co-transfer assay

decreased regulatory T cell number ( J:156942 )

♀ • no age-dependent increase in the frequency of Treg cells, as is seen in wild-type

increased T cell number ( J:156942 )

♀ • IL10-producing Foxp3^- (Tr1) cell numbers are increased

abnormal intraepithelial T cell morphology ( J:156942 )

♀ • a marked decrease in the size of the Treg subsets in the GALT compared to littermate controls

immune system

abnormal T cell differentiation ( J:156942 )

♀ • impairment in the ability of CD4 TN cells to generate iTreg cells, most prominently in the gut associated lymphoid tissues in a co-transfer assay

decreased regulatory T cell number ( J:156942 )

♀ • no age-dependent increase in the frequency of Treg cells, as is seen in wild-type

increased T cell number ( J:156942 )

♀ • IL10-producing Foxp3^- (Tr1) cell numbers are increased

abnormal intraepithelial T cell morphology ( J:156942 )

♀ • a marked decrease in the size of the Treg subsets in the GALT compared to littermate controls

abnormal gut-associated lymphoid tissue morphology ( J:156942 )

♀ • a marked decrease in the size of the Treg subsets in the GALT compared to littermate controls

abnormal Peyer's patch morphology ( J:156942 )

♀ • a marked decrease in the size of the Treg subsets in the Peyer's patch compared to littermate controls

abnormal mesenteric lymph node morphology ( J:156942 )

♀ • a marked decrease in the size of the Treg subsets in the MLN compared to littermate controls