Phenotypes associated with this allele

• Allele Symbol: Celsr1^tm1.1Fati
• Allele Name: targeted mutation 1.1, Fadel Tissir
• Allele ID: MGI:4430218
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Celsr1^tm1.1Fati/Celsr1^tm1.1Fati	involves: 129S1/Sv * 129X1/SvJ	MGI:4430219

Genotype
MGI:4430219

hm1

• Allelic Composition: Celsr1^tm1.1Fati/Celsr1^tm1.1Fati
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:157059 )

• about 20% die in utero with various degrees of neural tube opening

craniofacial

cranioschisis ( J:157059 )

• in some embryos

embryo

abnormal neural tube closure ( J:157059 )

• about 20% die in utero with various degrees of neural tube opening

limbs/digits/tail

kinked tail ( J:157059 )

nervous system

abnormal neural tube closure ( J:157059 )

• about 20% die in utero with various degrees of neural tube opening

skeleton

cranioschisis ( J:157059 )

• in some embryos

integument

whorled hair ( J:157059 )

• hairs form abnormal, whorl-like patterns that spiral around a few centers on the body and the head

• on the limbs, hairs do not point distally like in control animals, but are oriented in a rosettelike manner

abnormal hair follicle orientation ( J:157059 )

• follicles and hairs in areas located within a few millimeters from each other assume very different orientations