All Phenotypes Zfp24<tm1.2Pop> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Zfp24^tm1.2Pop
targeted mutation 1.2, Brian Popko
MGI:4429673

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Zfp24^tm1.2Pop/Zfp24^tm1.2Pop	involves: 129S4/SvJae * C57BL/6	MGI:4429675
ht2	Zfp24^hmcns/Zfp24^tm1.2Pop	involves: 129S4/SvJae * C3H/HeJ * C57BL/6	MGI:4429674

Allelic Composition	Zfp24^tm1.2Pop/Zfp24^tm1.2Pop
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zfp24^tm1.2Pop mutation (0 available); any Zfp24 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:156938 )

• die by 3.5 weeks

nervous system

tonic seizures ( J:156938 )

decreased oligodendrocyte number ( J:156938 )

• reduced number of post-mitotic and myelinating oligodendrocytes in the brainstem

• severe decrease in late-stage oligodendrocyte markers MOG and MBP in 5 day oligodendrocyte progenitor cell culture

abnormal myelin sheath morphology ( J:156938 )

• severe hypomyelination in the CNS

abnormal myelination ( J:156938 )

• a reduced ability of oligodendrocytes to myelinate wild-type retinal ganglion cell axons in culture

behavior/neurological

tremors ( J:156938 )