Phenotypes associated with this allele

• Allele Symbol: Tg(Htt-ATXN3*148Q)3746Thsc
• Allele Name: transgene insertion 3746, Thorsten Schmidt
• Allele ID: MGI:4429385
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Htt-ATXN3*148Q)3746Thsc/Tg(Htt-ATXN3*148Q)3746Thsc	involves: C57BL/6N	MGI:4429406
tg2	Tg(Htt-ATXN3*148Q)3746Thsc/0	involves: C57BL/6N	MGI:4429405

Genotype
MGI:4429406

tg1

• Allelic Composition: Tg(Htt-ATXN3*148Q)3746Thsc/Tg(Htt-ATXN3*148Q)3746Thsc
• Genetic Background: involves: C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

neuronal intranuclear inclusions ( J:156912 )

• at 18 months in the cerebellum and brainstem

Genotype
MGI:4429405

tg2

• Allelic Composition: Tg(Htt-ATXN3*148Q)3746Thsc/0
• Genetic Background: involves: C57BL/6N

behavior/neurological

abnormal motor learning ( J:156912 )

• mice fail to show improvement on a rotarod unlike wild-type mice

decreased anxiety-related response ( J:156912 )

• mice spend more time in the center of their home cage compared with wild-type mice

impaired coordination ( J:156912 )

• at 1 year of age

decreased locomotor activity ( J:156912 )

• mice exhibit decreased activity at the beginning of the dark phase compared with wild-type mice

hyperactivity ( J:156912 )

• mice exhibit increased activity in their home cage compared with wild-type mice

• mice exhibit increased activity at the end of the dark phase compared with wild-type mice

increased vertical activity ( J:156912 )

nervous system

neuronal intranuclear inclusions ( J:156912 )

• at 25 months in the cerebellum and brainstem

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Machado-Joseph disease		DOID:1440	OMIM:109150	J:156912