Analysis Tools
nervous system
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• at 18 months in the cerebellum and brainstem
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Allele Symbol Allele Name Allele ID |
Tg(Htt-ATXN3*148Q)3746Thsc transgene insertion 3746, Thorsten Schmidt MGI:4429385 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at 18 months in the cerebellum and brainstem
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice fail to show improvement on a rotarod unlike wild-type mice
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• mice spend more time in the center of their home cage compared with wild-type mice
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• at 1 year of age
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• mice exhibit decreased activity at the beginning of the dark phase compared with wild-type mice
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• mice exhibit increased activity in their home cage compared with wild-type mice
• mice exhibit increased activity at the end of the dark phase compared with wild-type mice
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• at 25 months in the cerebellum and brainstem
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Machado-Joseph disease | DOID:1440 |
OMIM:109150 |
J:156912 | |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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