All Phenotypes Ccnd1<tm4Pisc> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ccnd1^tm4Pisc
targeted mutation 4, Piotr Sicinski
MGI:4421801

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ccnd1^tm4Pisc/Ccnd1^tm4Pisc	involves: 129S4/SvJae * C57BL/6	MGI:4421803
ht2	Ccnd1^tm3Pisc/Ccnd1^tm4Pisc	involves: 129S4/SvJae * C57BL/6	MGI:4421804
cx3	Ccnd1^tm4Pisc/Ccnd1^tm4Pisc Tg(MMTV-Erbb2)NK1Mul/0	involves: 129S4/SvJae * C57BL/6 * FVB/N	MGI:4421802

Allelic Composition	Ccnd1^tm4Pisc/Ccnd1^tm4Pisc
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccnd1^tm4Pisc mutation (0 available); any Ccnd1 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:156591 )

• no defects in neurological development, mammary development, retinal morphology or body size are detected

Allelic Composition	Ccnd1^tm3Pisc/Ccnd1^tm4Pisc
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccnd1^tm3Pisc mutation (0 available); any Ccnd1 mutation (21 available)
Ccnd1^tm4Pisc mutation (0 available); any Ccnd1 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:156591 )

• no defects in neurological development, mammary development, retinal morphology or body size are detected

Allelic Composition	Ccnd1^tm4Pisc/Ccnd1^tm4Pisc Tg(MMTV-Erbb2)NK1Mul/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccnd1^tm4Pisc mutation (0 available); any Ccnd1 mutation (21 available)
Tg(MMTV-Erbb2)NK1Mul mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary adenocarcinoma incidence ( J:156591 )

• 50% of mice develop tumors by about 45 weeks, same rate of occurrence as transgene alone

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:156591 )

• 50% of mice develop tumors by about 45 weeks, same rate of occurrence as transgene alone

integument

increased mammary adenocarcinoma incidence ( J:156591 )

• 50% of mice develop tumors by about 45 weeks, same rate of occurrence as transgene alone

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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