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Allele Symbol Allele Name Allele ID |
Vamp8tm1.1Hong targeted mutation 1.1, Wanjin Hong MGI:4421511 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• slightly
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• Background Sensitivity: one-third of mice on a mixed 129P2/OlaHsd and C57BL/6 background exhibit overt renal degeneration compared with less than 10% of mice on a pure 129 background which exhibit moderate atrophy
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• all mice die by 10 months of age
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• mice on a pure C57BL/6 background hardly survive beyond weaning
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• in mice with severe hydronephrosis
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• severe
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• urine is much paler than in wild-type mice
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• 1-fold compared to in wild-type mice
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• adult mice exhibit kidney dilation and medulla atrophy unlike in wild-type mice
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• adult mice exhibit renal medulla atrophy unlike in wild-type mice
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• Background Sensitivity: one-third of mice on a mixed 129P2/OlaHsd and C57BL/6 background exhibit overt renal degeneration compared with less than 10% of mice on a pure 129 background which exhibit moderate atrophy
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• female mice drink more water than wild-type mice
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• urine is much paler than in wild-type mice
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• 1-fold compared to in wild-type mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/21/2024 MGI 6.23 |
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