Phenotypes associated with this allele

• Allele Symbol: Tg(Ins2-Cebpb)2Maka
• Allele Name: transgene insertion 2, Masato Kasuga
• Allele ID: MGI:4421493
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Ins2-Cebpb)2Maka/0	involves: C57BL/6	MGI:4421498

Genotype
MGI:4421498

tg1

• Allelic Composition: Tg(Ins2-Cebpb)2Maka/0
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Reduced beta cell mass in Tg(Ins2-Cebpb)2Maka/0 mice

endocrine/exocrine glands

decreased pancreatic beta cell mass ( J:156725 )

• at 8 weeks

abnormal pancreas physiology ( J:156725 )

• expression of a proliferation marker in the pancreas islet is decreased compared to in wild-type mice

increased pancreatic islet cell apoptosis ( J:156725 )

• expression of apoptosis markers in the pancreas islet is increased compared to in wild-type mice

decreased insulin secretion ( J:156725 )

• at 8 weeks

homeostasis/metabolism

decreased insulin secretion ( J:156725 )

• at 8 weeks

increased circulating glucose level ( J:156725 )

• at 4 and 6 weeks

decreased circulating insulin level ( J:156725 )

• at 8 weeks

cellular

increased pancreatic islet cell apoptosis ( J:156725 )

• expression of apoptosis markers in the pancreas islet is increased compared to in wild-type mice