Phenotypes associated with this allele

• Allele Symbol: Atf7^tm1Sis
• Allele Name: targeted mutation 1, Shunsuke Ishii
• Allele ID: MGI:4421144
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Atf7^tm1Sis/Atf7^tm1Sis	either: B6.Cg-Atf7^tm1Sis or (involves: C57BL/6 * CBA)	MGI:4421147

Genotype
MGI:4421147

hm1

• Allelic Composition: Atf7^tm1Sis/Atf7^tm1Sis
• Genetic Background: either: B6.Cg-Atf7^tm1Sis or (involves: C57BL/6 * CBA)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:156409 )

N • mice exhibit normal behavior in open field, elevated plus maze test, new environment, rotarod, forced-swim, and Morris water maze tests

increased anxiety-related response ( J:156409 )

• mice exhibit increased marble-burying behavior compared with wild-type mice

• isolation stress enhances marble-burying

increased startle reflex ( J:156409 )

• to a pulse-alone stimulus

nervous system

decreased prepulse inhibition ( J:156409 )

• mice exhibit a lower level of pre-pulse inhibition of the acoustic startle response compared with wild-type mice