Phenotypes associated with this allele

• Allele Symbol: Naca^tm1.1Star
• Allele Name: targeted mutation 1.1, Rene St-Arnaud
• Allele ID: MGI:4421140
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Naca^tm1.1Star/Naca^tm1.1Star	involves: 129/Sv * C57BL/6 * C57BL/6NCrl * DBA/2NCrl	MGI:4421142
ht2	Naca^tm1.1Star/Naca^+	involves: 129/Sv * C57BL/6 * C57BL/6NCrl * DBA/2NCrl	MGI:4421143

Genotype
MGI:4421142

hm1

• Allelic Composition: Naca^tm1.1Star/Naca^tm1.1Star
• Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6NCrl * DBA/2NCrl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

decreased bone volume ( J:156411 )

• bone volume to tissue volume is reduced compared to in wild-type mice

• however, the number of bone forming and bone resorbing cells is normal

abnormal osteocyte morphology ( J:156411 )

• expression of differentiation markers in osteocytes of the proximal tibia secondary spongiosa trabeculae is increased compared to in wild-type mice

increased osteocyte number ( J:156411 )

• mice exhibit an increase in the number of osteocytes per area in the trabeculae of the secondary spongiosa of the proximal tibia compared to in wild-type mice

abnormal bone trabecula morphology ( J:156411 )

• trabecular separation is increased compared to in wild-type mice

decreased bone trabecula number ( J:156411 )

• trabecular number is lower than in wild-type mice

decreased trabecular bone thickness ( J:156411 )

abnormal osteoid morphology ( J:156411 )

• osteoid surface over bone surface is reduced compared to in wild-type mice

decreased osteoid thickness ( J:156411 )

• mice exhibit lower mean osteoid thickness compared with wild-type mice

decreased osteoid volume ( J:156411 )

• bone volume to tissue volume is reduced compared to in wild-type mice

abnormal bone mineralization ( J:156411 )

• mineral apposition rates is decreased compared to in wild-type mice

• mineralization volume over bone volume is increased while mineralization lag time is decreased compared to in wild-type mice

• after 2 weeks after reaching confluency, cultured primary osteoblasts show more mineralization matrix deposition compared with similarly treated wild-type cells

decreased bone ossification ( J:156411 )

• bone formation rate is decreased compared to in wild-type mice

Genotype
MGI:4421143

ht2

• Allelic Composition: Naca^tm1.1Star/Naca⁺
• Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6NCrl * DBA/2NCrl

skeleton

decreased bone mineralization ( J:156411 )

• mineral apposition rate is decreased compared to in wild-type mice

decreased bone ossification ( J:156411 )

• bone formation rate is decreased compared to in wild-type mice