Phenotypes associated with this allele

• Allele Symbol: Ptgs2^tm1.1Wls
• Allele Name: targeted mutation 1.1, William L Smith
• Allele ID: MGI:4420987
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ptgs2^tm1.1Wls/Ptgs2^tm1.1Wls	B6.129-Ptgs2^tm1.1Wls	MGI:4420991

Genotype
MGI:4420991

hm1

• Allelic Composition: Ptgs2^tm1.1Wls/Ptgs2^tm1.1Wls
• Genetic Background: B6.129-Ptgs2^tm1.1Wls

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Hypertoprhy of glomeruli in Ptgs2^tm1Unc/Ptgs2^tm1Unc mice that is not seen in Ptgs2^tm1.1Wls/Ptgs2^tm1.1Wls mice

homeostasis/metabolism

impaired febrile response ( J:156331 )

• LPS-treated mice exhibit a greater increase in body temperature as long as 20 hours after treatment compared with wild-type mice

increased urine prostaglandin level ( J:156331 )

• at 12 weeks, urinary metabolite of prostaglandin in male mice is 50% higher than in wild-type mice

renal/urinary system

renal/urinary system phenotype ( J:156331 )

N • mice exhibit normal renal glomeruli

increased urine prostaglandin level ( J:156331 )

• at 12 weeks, urinary metabolite of prostaglandin in male mice is 50% higher than in wild-type mice

immune system

increased susceptibility to endotoxin shock ( J:156331 )

• LPS-treated mice exhibit a greater increase in body temperature as long as 20 hours after treatment compared with wild-type mice

reproductive system

reproductive system phenotype ( J:156331 )

N • female mice produce normal sized litters

cardiovascular system

cardiovascular system phenotype ( J:156331 )

N • mice exhibit normal cardiac morphology and physiology