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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(tetO-LRRK2)C77Cai
transgene insertion C77, Huaibin Cai
MGI:4420821
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Tg(Camk2a-tTA)1Mmay/0
Tg(tetO-LRRK2)C77Cai/0 		involves: C57BL/6 MGI:4420995
cx2
 		Tg(Camk2a-tTA)1Mmay/0
Tg(tetO-LRRK2)C77Cai/0
Tg(tetO-SNCA*A53T)E2Cai/0 		involves: C57BL/6 MGI:4420996


Genotype
MGI:4420995
cx1
Allelic
Composition		 Tg(Camk2a-tTA)1Mmay/0
Tg(tetO-LRRK2)C77Cai/0
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Camk2a-tTA)1Mmay mutation (8 available)
Tg(tetO-LRRK2)C77Cai mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:156512 )
N
• no neuronal degeneration is observed at 1 month in the striatum or cortex of LRRK2WT-L mice




Genotype
MGI:4420996
cx2
Allelic
Composition		 Tg(Camk2a-tTA)1Mmay/0
Tg(tetO-LRRK2)C77Cai/0
Tg(tetO-SNCA*A53T)E2Cai/0
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Camk2a-tTA)1Mmay mutation (8 available)
Tg(tetO-LRRK2)C77Cai mutation (0 available)
Tg(tetO-SNCA*A53T)E2Cai mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal nervous system morphology ( J:156512 )
• increasing accumulation of alpha-synuclein is detected in cell bodies in brains of A53T/LRRK2WT-L at 1 month compared to LRRK2WT-L animals
microgliosis ( J:156512 )
• increased microglial activation is observed in the brain
astrocytosis ( J:156512 )
• A53T/LRRK2WT-L mice show significant elevation of GFAP-positive astrocytes in the striatum compared to A53T mice
neurodegeneration ( J:156512 )
• neurodegeneration is accelerated in the striatum
abnormal nervous system physiology ( J:156512 )
• increasing accumulation of alpha-synuclein is detected in cell bodies at 1 month

behavior/neurological
abnormal locomotor behavior ( J:156512 )
• mice show no apparent motor phenotype up to 6 months of age

hematopoietic system
microgliosis ( J:156512 )
• increased microglial activation is observed in the brain

immune system
microgliosis ( J:156512 )
• increased microglial activation is observed in the brain




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory