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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(tetO-LRRK2*)D10Cai
transgene insertion D10, Huaibin Cai
MGI:4420818
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Tg(Camk2a-tTA)1Mmay/0
Tg(tetO-LRRK2*)D10Cai/0 		involves: C57BL/6 MGI:4420997
cx2
 		Tg(Camk2a-tTA)1Mmay/0
Tg(tetO-LRRK2*)D10Cai/0
Tg(tetO-SNCA*A53T)E2Cai/0 		involves: C57BL/6 MGI:4420998


Genotype
MGI:4420997
cx1
Allelic
Composition		 Tg(Camk2a-tTA)1Mmay/0
Tg(tetO-LRRK2*)D10Cai/0
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Camk2a-tTA)1Mmay mutation (8 available)
Tg(tetO-LRRK2*)D10Cai mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal neuron morphology ( J:156512 )
• increased framentation of the Golgi complex is observed in KD mice




Genotype
MGI:4420998
cx2
Allelic
Composition		 Tg(Camk2a-tTA)1Mmay/0
Tg(tetO-LRRK2*)D10Cai/0
Tg(tetO-SNCA*A53T)E2Cai/0
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Camk2a-tTA)1Mmay mutation (8 available)
Tg(tetO-LRRK2*)D10Cai mutation (0 available)
Tg(tetO-SNCA*A53T)E2Cai mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal nervous system morphology ( J:156512 )
• increasing accumulation of alpha-synuclein is detected in cell bodies at 1 month in A53T/KD mice compared to KD animals
abnormal neuron morphology ( J:156512 )
• increased framentation of the Golgi complex is observed
abnormal nervous system physiology ( J:156512 )
• neuropathology is accelerated in A53T/KD mice compared to A53T mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory