Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tubb4atm1(KOMP)Wtsi mutation
(1 available);
any
Tubb4a mutation
(30 available)
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mortality/aging
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N |
• mice exhibit a normal lifespan
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behavior/neurological
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N |
• mice do not develop tremulous motor phenotypes or ataxia at advanced age and show no differences in rotarod performance or grip strength up to 1 year
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tubb4aJit mutation
(0 available);
any
Tubb4a mutation
(30 available)
Tubb4atm1(KOMP)Wtsi mutation
(1 available);
any
Tubb4a mutation
(30 available)
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mortality/aging
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• mice survive up to approximately 14 weeks
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behavior/neurological
nervous system
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• mice show progressive degeneration of granule cell neurons such that the inner granule layer is largely devoid of granule cell neurons at P48
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• P95 mice have severely atrophic cerebellum with the inner granule layer largely devoid of granule cell neurons at P48
• however, cerebellar phenotypes are less severe than in homozygous Tubb4aJit mice
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• reduction in white matter tracts such as corpus callosum, anterior commissures, and striatal fascicles at P95
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• mice show progressive degeneration of myelin with reduced myelin at P48 and P95, however reduction in myelin is not as severe as in in homozygous Tubb4aJit mice
• cerebellum is severely demyelinated at P95
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|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tubb4atm1(KOMP)Wtsi mutation
(1 available);
any
Tubb4a mutation
(30 available)
Tubb4btm2b(EUCOMM)Wtsi mutation
(0 available);
any
Tubb4b mutation
(18 available)
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cellular
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• severe truncation of cilia on multi-ciliated cells although occasional longer cilia are seen
• no cilia display the symmetric 9 microtuble doublet axonemes, all show the presence of singlets
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respiratory system
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• severe truncation of cilia on multi-ciliated cells although occasional longer cilia are seen
• no cilia display the symmetric 9 microtuble doublet axonemes, all show the presence of singlets
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Analysis Tools